Activity of N-Acetylcysteine Alone and in Combination with Colistin against Pseudomonas aeruginosa Biofilms and Transcriptomic Response to N-Acetylcysteine Exposure
| Autor: | Felice Valzano, Selene Rebecca Boncompagni, Maria Micieli, Tiziana Di Maggio, Vincenzo Di Pilato, Lorenzo Colombini, Francesco Santoro, Gianni Pozzi, Gian Maria Rossolini, Lucia Pallecchi |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Microbiology (medical)
General Immunology and Microbiology Ecology Cystic Fibrosis Physiology Colistin transcriptomic response Cell Biology Microbial Sensitivity Tests N-acetylcysteine Acetylcysteine Anti-Bacterial Agents Infectious Diseases synergism Biofilms Pseudomonas aeruginosa Genetics biofilms colistin cystic fibrosis Disease Progression Humans Transcriptome Pseudomonas Infections |
| Popis: | Pseudomonas aeruginosa biofilm-related chronic lung colonization contributes to cystic fibrosis (CF) disease progression. Colistin is often a last-resort antibiotic for the treatment of such P. aeruginosa infections, and it has been increasingly used in CF, especially by nebulization. N -acetylcysteine (NAC) is a mucolytic agent with antioxidant activity, commonly administered with antibiotics for the treatment of lower respiratory tract infections. |
| Databáze: | OpenAIRE |
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