Relative contribution of free-virus and synaptic transmission to the spread of HIV-1 through target cell populations
| Autor: | Benjamin Trinité, Dominik Wodarz, Natalia L. Komarova, Igor Voznesensky, Daniela Anghelina, David N. Levy |
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| Rok vydání: | 2013 |
| Předmět: |
CD4-Positive T-Lymphocytes
viruses Cell Population Human immunodeficiency virus (HIV) HIV Infections Biology Neurotransmission Virus Replication medicine.disease_cause Models Biological Jurkat cells Virus law.invention Jurkat Cells law medicine Humans education education.field_of_study Virion Flow Cytometry Agricultural and Biological Sciences (miscellaneous) Virology Transmission (mechanics) medicine.anatomical_structure Viral replication HIV-1 Population Ecology General Agricultural and Biological Sciences |
| Zdroj: | Biology Letters. 9:20121049 |
| ISSN: | 1744-957X 1744-9561 |
| DOI: | 10.1098/rsbl.2012.1049 |
| Popis: | Human immunodeficiency virus can spread through target cells by transmission of cell-free virus or directly from cell-to-cell via formation of virological synapses. Although cell-to-cell transmission has been described as much more efficient than cell-free infection, the relative contribution of the two transmission pathways to virus growth during multiple rounds of replication remains poorly defined. Here, we fit a mathematical model to previously published and newly generated in vitro data, and determine that free-virus and synaptic transmission contribute approximately equally to the growth of the virus population. |
| Databáze: | OpenAIRE |
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