Systematic review, meta-analysis and regression of randomised controlled trials reporting an association between an intake of circa 25 g soya protein per day and blood cholesterol
| Autor: | Tanya A. Haffner, Janice I. Harland |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Apolipoprotein B Hypercholesterolemia Blood lipids Gastroenterology chemistry.chemical_compound Internal medicine medicine Humans Randomized Controlled Trials as Topic biology Dose-Response Relationship Drug Vascular disease Cholesterol business.industry Anticholesteremic Agents food and beverages Cholesterol LDL medicine.disease Confidence interval Dose–response relationship Endocrinology chemistry Meta-analysis Low-density lipoprotein biology.protein Soybean Proteins lipids (amino acids peptides and proteins) Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Atherosclerosis. 200(1) |
| ISSN: | 1879-1484 |
| Popis: | To determine the effect of a daily intake of circa 25 g soya protein on blood lipids in adults with normal or mildly elevated cholesterolaemia.Medline and other scientific databases were searched to identify randomised controlled trials (RCTs); these were systematically reviewed against pre-determined criteria. Eligible RCTs evaluated the effect of 25 g (range 15-40 g) soya protein on measures of blood lipids. Results from RCTs were pooled using standard meta-analysis methods.Thirty studies containing 42 treatment arms (n=2913), with an average soya protein intake of 26.9 g met the inclusion criteria. Soya protein inclusion led to reductions in standard difference in mean low density lipoprotein (LDL), total cholesterol and blood triglycerides of 0.23 mmol/L (95% confidence interval (CI) -0.160 to -0.306, p0.0001), 0.22 mmol/L (95% CI -0.142 to -0.291, p0.0001) and 0.08 mmol/L (95% CI -0.004 to -0.158, p=0.04), respectively. There was no effect on mean difference in apolipoprotein A (ApoA), but ApoB was reduced by 0.021 g/L (p=0.01) in the soya group. Meta-regression analysis indicated no dose response relationship between soya protein intake in the range of 15-40 g and standard difference in LDL or HDL. All data were tested for heterogeneity and none identified.The inclusion of modest amounts soya protein (ca. 25 g) into the diet of adults with normal or mild hypercholesterolaemia resulted in small, highly significant reductions in total and LDL cholesterol, equivalent to ca. 6% LDL reduction. This practically achievable intake, particularly when combined with other dietary measures, can make a useful contribution to blood cholesterol management. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect