Antibodies to advanced glycation end products in children with diabetes mellitus
| Autor: | S. Baydanoff, P. Christova, Ch. Petrova, G. Nicoloff |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Glycation End Products
Advanced Male medicine.medical_specialty Adolescent Physiology Glycation Internal medicine Diabetes mellitus medicine Humans Child Autoantibodies Pharmacology Analysis of Variance Type 1 diabetes Chi-Square Distribution biology business.industry medicine.disease Structure and function Diabetes Mellitus Type 1 Endocrinology Child Preschool biology.protein Molecular Medicine Female Microalbuminuria Antibody Complication business Retinopathy |
| Zdroj: | Vascular Pharmacology. 39:39-45 |
| ISSN: | 1537-1891 |
| DOI: | 10.1016/s1537-1891(02)00248-3 |
| Popis: | The tissue accumulation of advanced glycation end products (AGE) alters the structure and function of long-lived proteins. A number of studies have shown that tissue accumulation of AGE correlates with the severity of diabetic complications. Proteins containing AGE are highly immunogenic and anti-AGE antibodies were found in sera of diabetic rats and human. Considering the potential use of anti-AGE antibodies as a marker of AGE deposition during diabetes, we have investigated, by competitive ELISA, the presence of anti-AGE antibodies in sera of 58 children with Type 1 diabetes mellitus. The patients were studied for the period of 5 years. Positive for anti-AGE antibodies were 19 children with diabetes. Fourteen of them showed initial data for vascular complications. Anti-AGE antibodies were related to age ( r =.25, P =.024), duration of diabetes ( r =.41, P =.0001), HbA1c ( r =.27, P =.016), microalbuminuria ( r =.41, P =.0001), retinopathy ( r =.35, P =.001), triglycerides ( r =.27, P =.016), and total cholesterol ( r =.19, P =.05). In conclusion, our study showed that the investigation of the levels and dynamics of anti-AGE antibodies might give the possibility for early diagnosis and prognosis of the severity of diabetic late complications. |
| Databáze: | OpenAIRE |
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