IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation
| Autor: | Sven Seys, Maho Nagasawa, Suzanne M. Bal, Wytske Fokkens, Hajar Aglmous, Medya Shikhagaie, Xavier Romero Ros, Chantal M. A. Kradolfer, Balthasar A. Heesters, Korneliusz Golebski, P W Hellings, Cornelis M. van Drunen, Hergen Spits, Sophie van Tol |
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| Přispěvatelé: | Cell Biology and Histology, Graduate School, AGEM - Digestive immunity, AII - Inflammatory diseases, Clinical Haematology, Ear, Nose and Throat, Experimental Immunology |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Cystic Fibrosis Neutrophils Cell Plasticity Interleukin-1beta General Physics and Astronomy 02 engineering and technology Interleukin-23 Mice Interleukin 23 Nasal polyps lcsh:Science skin and connective tissue diseases Multidisciplinary Interleukin-17 Innate lymphoid cell Transdifferentiation ASSOCIATION Middle Aged 021001 nanoscience & nanotechnology Multidisciplinary Sciences Science & Technology - Other Topics Mucosal immunology Female Interleukin 17 medicine.symptom 0210 nano-technology VITAMIN-D DEFICIENCY EXPRESSION Adult Science INNATE LYMPHOID-CELLS Innate lymphoid cells Article General Biochemistry Genetics and Molecular Biology Cell Line Young Adult 03 medical and health sciences Nasal Polyps Immunity REPRESENTS medicine Animals Humans TRAFFICKING Secretion Inflammation Science & Technology CYSTIC-FIBROSIS business.industry INTERLEUKIN-17 General Chemistry medicine.disease Immunity Innate Neutrophilia body regions EXACERBATIONS Nasal Mucosa 030104 developmental biology Immunology T-CELLS Th17 Cells lcsh:Q business |
| Zdroj: | Nature communications, 10(1):2162. Nature Publishing Group Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019) Nature Communications |
| Popis: | Innate lymphoid cells (ILCs) are crucial for the immune surveillance at mucosal sites. ILCs coordinate early eradication of pathogens and contribute to tissue healing and remodeling, features that are dysfunctional in patients with cystic fibrosis (CF). The mechanisms by which ILCs contribute to CF-immunopathology are ill-defined. Here, we show that group 2 ILCs (ILC2s) transdifferentiated into IL-17-secreting cells in the presence of the epithelial-derived cytokines IL-1β, IL-23 and TGF-β. This conversion is abrogated by IL-4 or vitamin D3. IL-17 producing ILC2s induce IL-8 secretion by epithelial cells and their presence in nasal polyps of CF patients is associated with neutrophilia. Our data suggest that ILC2s undergo transdifferentiation in CF nasal polyps in response to local cytokines, which are induced by infectious agents. Innate lymphoid cells (ILCs) play critical immunological roles including immune surveillance at mucosal sites. Here the authors show that during nasal inflammation pathogen-induced cytokine production guides the differentiation of ILCs. |
| Databáze: | OpenAIRE |
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