Interstitial lung disease in Egyptian patients with rheumatoid arthritis: Frequency, pattern and correlation with clinical manifestations and anti-citrullinated peptide antibodies level
| Autor: | Heba Mousa, Hala Lotfy Fayed, Nermeen Khairy, Samia H. Fadda, Radwa Taha |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
musculoskeletal diseases
lcsh:Immunologic diseases. Allergy medicine.medical_specialty Gastroenterology Correlation 03 medical and health sciences 0302 clinical medicine Rheumatology Usual interstitial pneumonia Internal medicine Medicine 030203 arthritis & rheumatology biology business.industry Interstitial lung disease Morning stiffness respiratory system medicine.disease Clinical disease respiratory tract diseases Titer 030228 respiratory system Rheumatoid arthritis biology.protein Antibody business lcsh:RC581-607 |
| Zdroj: | Egyptian Rheumatologist, Vol 40, Iss 3, Pp 155-160 (2018) |
| ISSN: | 1110-1164 |
| Popis: | Introduction: Interstitial lung disease (ILD) represents 13% of the overall mortality in rheumatoid arthritis (RA) patients. Aim of the work: To determine the frequency and pattern of ILD among RA patients, correlate it with clinical manifestations and with anti-citrullinated peptide antibodies (ACPA) titer. Patients and methods: This study included 88 RA patients. ILD was diagnosed by high-resolution computed tomography (HRCT) and assessed by a severity score. Disease activity was assessed by clinical disease activity index (CDAI) and functional status by the modified health assessment questionnaire (MHAQ). Serum ACPA titer was assayed by ELISA. Results: The mean age of the patients was 50.15 ± 9 years, disease duration was 10.2 ± 6.2 years and they were 75 females and 13 males. ACPA was positive in 84 (95.5%). The frequency of ILD among RA patients was 71.6%. ILD patterns were: usual interstitial pneumonia (UIP) 62%, non-specific interstitial pneumonia (NSIP) 27%, others (Cryptogenic and mixed) in 11%. In RA-ILD, the mean ACPA titer was 225 ± 121.5 U/mL versus 154.3 ± 121.8 U/mL in RA only. In RA-ILD, ACPA titer negatively correlated with morning stiffness, CDAI, MHAQ and six-minute walk test (r = −0.3, p = .008, r = −0.6, p |
| Databáze: | OpenAIRE |
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