Effect of dietary vitamin C on compression injury of the spinal cord in a rat mutant unable to synthesize ascorbic acid and its correlation with that of vitamin E
| Autor: | Yoshitaka Hamada, D Katoh, Shinsuke Katoh, Takaaki Ikata, Kenji Fukuzawa |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Vitamin
medicine.medical_specialty Movement medicine.medical_treatment Ascorbic Acid Thiobarbituric Acid Reactive Substances chemistry.chemical_compound Spinal cord compression Internal medicine medicine Animals Vitamin E Rats Wistar Ascorbic Acid Deficiency Spinal cord injury Vitamin C business.industry Free Radical Scavengers General Medicine medicine.disease Spinal cord Ascorbic acid Diet Hindlimb Rats Surgery Endocrinology medicine.anatomical_structure Spinal Cord Neurology chemistry Mutation Neurology (clinical) business Spinal Cord Compression |
| Zdroj: | Spinal Cord. 34:234-238 |
| ISSN: | 1476-5624 1362-4393 |
| DOI: | 10.1038/sc.1996.43 |
| Popis: | The roles of vitamin C on secondary pathological changes after spinal cord injury were investigated by evaluating the effects of dietary vitamin C on experimental spinal cord injury in a mutant strain of Wistar rats unable to synthesize ascorbic acid (ODS rats). Two groups of ODS rats were given vitamin C-deficient or vitamin C-supplemented diet for 1 week before injury. Motor disturbance induced by spinal cord injury was found to be greater in the vitamin C-deficient group. Histologically, the area of bleeding in the spinal cord was also greater in the vitamin C-deficient group. The levels of ascorbic acid and alpha-tocopherol in the spinal cord tissue and serum decreased during and after compression injury of the spinal cord. The decrease of alpha-tocopherol was similar in the two groups. However, the decrease of ascorbic acid was greater in the vitamin C-supplemented group. These results indicated that their protective effects against spinal cord injury are through scavenging water-soluble free radicals by vitamin C and lipid-soluble by vitamin E, and the effects of these vitamins were suggested to be independent. |
| Databáze: | OpenAIRE |
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