Neuronal HMGB1 in nucleus accumbens regulates cocaine reward memory
| Autor: | Huan-Huan Zhao, Fang Wang, Jin-Gang He, Hai Zhang, Jun-Feng Xu, Hui-Ling Zheng, Zhuang-Li Hu, Pei-Wei Zhang, Jian-Guo Chen, Shuang-Qi Gao, Zu-Cheng Shen |
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| Rok vydání: | 2019 |
| Předmět: |
Male
media_common.quotation_subject Central nervous system Medicine (miscellaneous) chemical and pharmacologic phenomena Nucleus accumbens HMGB1 Nucleus Accumbens Rats Sprague-Dawley Cocaine-Related Disorders 03 medical and health sciences 0302 clinical medicine Immune system Cocaine Reward Memory medicine Animals HMGB1 Protein media_common Neurons Pharmacology biology Addiction Glutamate receptor Conditioned place preference Rats 030227 psychiatry Disease Models Animal Psychiatry and Mental health medicine.anatomical_structure biology.protein Nucleus Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Addiction Biology. 25 |
| ISSN: | 1369-1600 1355-6215 |
| Popis: | Cocaine is a common abused drug that can induce abnormal synaptic and immune responses in the central nervous system (CNS). High mobility group box 1 (HMGB1) is one kind of inflammatory molecules that is expressed both on neurons and immune cells. Previous studies of HMGB1 in the CNS have largely focused on immune function, and the role of HMGB1 in neurons and cocaine addiction remains unknown. Here, we show that cocaine exposure induced the translocation and release of HMGB1 in the nucleus accumbens (NAc) neurons. Gain and loss of HMGB1 in the NAc bidirectionally regulate cocaine-induced conditioned place preference. From the nucleus to the cytosol, HMGB1 binds to glutamate receptor subunits (GluA2/GluN2B) on the membrane, which regulates cocaine-induced synaptic adaptation and the formation of cocaine-related memory. These data unveil the role of HMGB1 in neurons and provide the evidence for the HMGB1 involvement in drug addiction. |
| Databáze: | OpenAIRE |
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