The effect of albumin administration on renal dysfunction after experimental surgical obstructive jaundice in male rats
Autor: | Abeir A. Shalaby, Mohamed Fathelbab, Abdel-Aleem A. El-Saba, Ramadan A. Saad |
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Rok vydání: | 2016 |
Předmět: |
medicine.medical_specialty
Renal function Kidney medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Hepatorenal syndrome Internal medicine Medicine Creatinine business.industry Bile duct Albumin Glutathione Bile duct ligation medicine.disease Rats medicine.anatomical_structure Endocrinology Liver chemistry 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology business Oxidative stress |
Zdroj: | Journal of Taibah University for Science. 10:877-886 |
ISSN: | 1658-3655 |
Popis: | The aim was to study the influence of albumin supplementation on the changes of the kidney function and structure in cirrhotic rats induced by common bile duct ligation (BDL). Twenty-four male albino rats weighing 200–250 g were divided into Group I: 6 rats underwent laparotomy alone, and the bile duct was only dissected from the surrounding tissue; Group II: 6 rats underwent a sham operation and received 2% albumin in their drinking water; Group III: 6 rats were subjected to bile duct ligation only; and Group IV: 6 rats were subjected to bile duct ligation and received a daily albumin 2% in drinking water. All rats were sacrificed after 4 weeks. We measured the liver and kidney functions and oxidative stress markers in the renal tissue and conducted a histological evaluation of the liver and kidney. The liver enzymes were decreased, but there was no significant difference in the bilirubin levels in group IV compared to group III. There was a significant elevation of serum creatinine in group III compared to group II, and serum creatinine was attenuated in group IV. The renal tissue catalase activity and reduced glutathione, as well as the nitric oxide levels, were significantly increased in group IV and were elevated in group III. Histologically, the livers of group IV showed degeneration and inflammatory cell infiltration with regeneration areas in which normal hepatocytes appeared. The kidneys of group IV showed recovery as well as areas of inflammatory cell infiltration. Some tubules appeared with normal epithelial lining. In conclusion, the results suggest that albumin partially improves the renal functions and structures after their disturbances as a result of BDL. |
Databáze: | OpenAIRE |
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