The role of serum and gastric juice levels of carcinoembryonic antigen, CA19.9 and CA72.4 in patients with gastric cancer
Autor: | Alberto Cianetti, Gianluca Costa, Paola Vannini, Gianluca Mazzoni, Adriano Tocchi, Gianluca Liotta, Luca Lepre |
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Rok vydání: | 1998 |
Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Pathology CA-19-9 Antigen endocrine system diseases Adenocarcinoma Gastroenterology Carcinoembryonic antigen Predictive Value of Tests Stomach Neoplasms Internal medicine Biomarkers Tumor medicine Humans Antigens Tumor-Associated Carbohydrate Neoplasm Invasiveness Survival analysis Aged Neoplasm Staging Tumor marker Aged 80 and over Univariate analysis Gastric Juice Hematology biology business.industry Stomach digestive oral and skin physiology Cancer General Medicine Middle Aged medicine.disease Survival Analysis digestive system diseases Carcinoembryonic Antigen medicine.anatomical_structure Oncology Lymphatic Metastasis biology.protein Female CA19-9 business |
Zdroj: | Journal of Cancer Research and Clinical Oncology. 124:450-455 |
ISSN: | 1432-1335 0171-5216 |
Popis: | Purpose: The aim of the present study was to investigate carcinoembryonic antigen (CEA), CA19.9, and CA72.4 in the serum and gastric juice of patients with gastric cancer. Methods: Serum and gastric juice tumor markers CEA, CA19.9, and CA72.4 were measured in 59 patients who had gastric adenocarcinomas and were undergoing curative gastrectomy. The same markers were measured in 47 patients with benign gastric disorders and in 40 healthy subjects. The correlation between the serum and gastric juice levels of tumor markers and several clinicopathological factors were evaluated by univariate analysis. The significance of the tumor markers as prognostic factors was assessed both by univariate and multivariate analysis. Results: The positivity rates of serum CEA, CA19.9, and CA72.4 were 57.6%, 38.9%, and 18.6% respectively. The positivity rates of gastric juice CEA, CA19.9, and CA72.4 were 62.7%, 30.5%, and 23.7% respectively. The combination of serum and gastric juice markers gave a positivity of 81.3%. There was no correlation between serum and gastric juice level of each tumor marker. Positivity of gastric juice markers did not correlate with prognosis. A significant difference in prognosis was observed between patients positive and negative for serum CEA and CA19.9. Multivariate analysis also revealed that serum CEA and CA19.9 levels were independent prognostic factors. Conclusions: Levels of both serum and gastric juice tumor markers continue to have only limited diagnostic usefulness in gastric cancer patients. CEA and CA19.9 in the preoperative sera are good prognostic factors, whereas the presence of tumor markers in the gastric juice does not play any prognostic role. |
Databáze: | OpenAIRE |
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