First Detection of a Circulating Recombinant Form of HIV-1 CRF01_AE/08_BC (CRF105_0108) with Drug-Resistant Mutations in Sichuan, China
| Autor: | Aobo Dong, Yiming Shao, Shuiling Qu, Jing Hu, Lingjie Liao, Kang Li, Jun Yin, Yuhua Ruan, Lin Xiao, Ruihua Kang, Hui Xing, Jihong Xing, Shu Liang, Chang Song, Lei Liu, Yi Feng |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male China Nevirapine Efavirenz Immunology Human immunodeficiency virus (HIV) HIV Infections Drug resistance Genome Viral Biology medicine.disease_cause law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Phylogenetics law Virology Drug Resistance Viral medicine Humans 030212 general & internal medicine Phylogeny Aged Recombination Genetic Phylogenetic tree Breakpoint virus diseases Sequence Analysis DNA Middle Aged 030104 developmental biology Infectious Diseases chemistry Mutation Recombinant DNA HIV-1 RNA Viral medicine.drug |
| Zdroj: | AIDS research and human retroviruses. 36(7) |
| ISSN: | 1931-8405 |
| Popis: | In this study, we identified a novel circulating recombinant form (CRF) of HIV (CRF105_0108) in a total of five patients with no obvious epidemiological linkage in Sichuan, China. Four strains were found in this study, and another strain (XC2014EU01) was reported in a previous study. The phylogenetic analysis of the five near full-length genomes showed that a CRF08_BC segment was inserted into the CRF01_AE backbone with one recombinant breakpoint in the pol region, which is the first HIV-1 CRF of CRF01_AE and CRF08_BC. Three genetic sequences had drug-resistant mutations, E138Q and V179D, indicating that there were low resistance levels to efavirenz (EFV) and nevirapine (NVP) in Liangshan Yi Autonomous Prefecture. CRF105_0108 increases the diversity and complexity of the prevalent HIV-1 CRFs in Sichuan. Simultaneously, drug-resistant mutations in this CRF may influence the efficacy of highly active antiretroviral treatments (ARTs) in Liangshan Yi Autonomous Prefecture. |
| Databáze: | OpenAIRE |
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