Three Cases of Bullous Pemphigoid Associated with Dipeptidyl Peptidase-4 Inhibitors - One due to Linagliptin
| Autor: | Francisco Camacho-Martínez, Francisco J. Martín-Gutiérrez, Francisco Manuel Ildefonso Mendonça, Juan J. Ríos-Martín |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Pemphigoid Pyrrolidines Adamantane Linagliptin Dermatology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Nitriles Pemphigoid Bullous medicine Humans Vildagliptin skin and connective tissue diseases Dipeptidyl peptidase-4 Aged Dipeptidyl-Peptidase IV Inhibitors Aged 80 and over integumentary system business.industry medicine.disease eye diseases 030104 developmental biology Female Drug Eruptions sense organs Bullous pemphigoid business medicine.drug Blistering disease |
| Zdroj: | Dermatology. 232:249-253 |
| ISSN: | 1421-9832 1018-8665 |
| DOI: | 10.1159/000443330 |
| Popis: | Background: Bullous pemphigoid (BP) is an acquired subepidermal autoimmune blistering disease in which there are humoral and cellular responses against the BP180 and BP230 antigens. Dipeptidyl peptidase (DPP)-4 inhibitors enhance endogenous glucagon peptide-1 and glucose-dependent insulinotropic polypeptide secretion with food intake, which leads to insulin secretion, as well as to the reduction of glucagon secretion. Recently, several cases of DPP-4 inhibitor-associated BP have been reported. Objectives: To report 3 cases of DPP-4 inhibitor-associated BP, one of which is due to linagliptin use, as well as to review all currently published cases of DPP-4 inhibitor-associated BP. Case Reports: Three patients diagnosed with BP at our department showed a clear temporal relationship between the introduction of DPP-4 for the treatment of diabetes and the onset of BP. One case was due to linagliptin use, while the other 2 cases were due to an association with vildagliptin-metformin use. Conclusions: This is the first report of linagliptin-associated BP. Furthermore, 2 other cases of vildagliptin-associated BP are reported. |
| Databáze: | OpenAIRE |
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