Therapeutic effect of okra extract on gestational diabetes mellitus rats induced by streptozotocin
| Autor: | Feng-Tai Miao, Zhao-Hua Tian, Qiao-Hong Wang, Li-Chen Guo, Na Lei, Xia Zhang |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Antioxidant endocrine system diseases medicine.medical_treatment medicine.disease_cause Gestational diabetes mellitus Insulin resistance Internal medicine medicine Medicine(all) Fetus Pregnancy Traditional medicine Okra extract business.industry Therapeutic effect Antioxidant enzyme General Medicine medicine.disease Streptozotocin Pregnant rats Gestational diabetes Endocrinology business Oxidative stress medicine.drug |
| Zdroj: | Asian Pacific Journal of Tropical Medicine. 8(12):1038-1042 |
| ISSN: | 1995-7645 |
| DOI: | 10.1016/j.apjtm.2015.11.002 |
| Popis: | ObjectiveTo explore the effect of okra extract on gestational diabetes mellitus (GDM) rats and its probable molecular mechanism.MethodsA total of 30 female SD rats were caged with male rats for pregnancy, 27 pregnant rats were obtained and weighed. The pregnant rats were equally randomized into the control group, GDM group and intervention group. Once the pregnancy was verified, GDM group and intervention group were given 45 mg/kg streptozotocin by peritoneal injection for inducing GDM, control group was given equal volume of citrate buffer. Once the model was established successfully, intervention group was administered orally the solution containing 200 mg/kg/d okra extract, the other groups were given the diet and water only. On the 19th day of pregnancy, the blood samples and fetal rats of all groups were collected, fetal rats weight and placental weight was recorded and the serum glucose, lipids, serum insulin and C-peptide of pregnant rats before the delivery were determined.ResultsThe pregnant rats weight before the delivery, fetal rats weight and placental weight of GDM group were lower than control group and intervention group (P 0.05). Antioxidant enzymes levels of GDM group in liver and pancreas tissues were lower than the other groups, and after treatment of okra extract, antioxidant enzymes levels in liver and pancreas tissues were equivalent to control group (P > 0.05).ConclusionsOkra extract, rich in antioxidant substances, could avoid the excessive consuming of antioxidant enzymes, then, suppresses the oxidative stress and insulin resistance, thereby improving blood glucose level of GDM rats. |
| Databáze: | OpenAIRE |
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