Arterial input function placement for accurate CT perfusion map construction in acute stroke
| Autor: | Pina C. Sanelli, R. Gilberto Gonzalez, Shahmir Kamalian, Michael H. Lev, Pamela W. Schaefer, Karen L. Furie, Gregory V. Goldmakher, Rafael M. Ferreira |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Perfusion Imaging Infarction Perfusion scanning Sensitivity and Specificity Article medicine.artery medicine Humans Radiology Nuclear Medicine and imaging cardiovascular diseases Stroke Aged Aged 80 and over medicine.diagnostic_test business.industry Reproducibility of Results Infarction Middle Cerebral Artery General Medicine Middle Aged medicine.disease Cerebral Angiography Cerebral blood flow Middle cerebral artery Acute Disease Radiographic Image Interpretation Computer-Assisted Female Tomography Radiology Nuclear medicine business Tomography X-Ray Computed Perfusion Algorithms circulatory and respiratory physiology Cerebral angiography |
| Zdroj: | AJR. American journal of roentgenology. 194(5) |
| ISSN: | 1546-3141 |
| Popis: | The objective of our study was to evaluate the effect of varying arterial input function (AIF) placement on the qualitative and quantitative CT perfusion parameters.Retrospective analysis of CT perfusion data was performed on 14 acute stroke patients with a proximal middle cerebral artery (MCA) clot. Cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) maps were constructed using a systematic method by varying only the AIF placement in four positions relative to the MCA clot including proximal and distal to the clot in the ipsilateral and contralateral hemispheres. Two postprocessing software programs were used to evaluate the effect of AIF placement on perfusion parameters using a delay-insensitive deconvolution method compared with a standard deconvolution method.One hundred sixty-eight CT perfusion maps were constructed for each software package. Both software programs generated a mean CBF at the infarct core of12 mL/100 g/min and a mean CBV of2 mL/100 g for AIF placement proximal to the clot in the ipsilateral hemisphere and proximal and distal to the clot in the contralateral hemisphere. For AIF placement distal to the clot in the ipsilateral hemisphere, the mean CBF significantly increased to 17.3 mL/100 g/min with delay-insensitive software and to 19.4 mL/100 g/min with standard software (p0.05). The mean MTT was significantly decreased for this AIF position. Furthermore, this AIF position yielded qualitatively different parametric maps, being most pronounced with MTT and CBF. Overall, CBV was least affected by AIF location.For postprocessing of accurate quantitative CT perfusion maps, laterality of the AIF location is less important than avoiding AIF placement distal to the clot as detected on CT angiography. This pitfall is less severe with deconvolution-based software programs using a delay-insensitive technique than with those using a standard deconvolution method. |
| Databáze: | OpenAIRE |
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