Ketamine protects cultured astrocytes from glutamate-induced swelling
| Autor: | Lillian Chu, Pak H. Chan |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
Cell Membrane Permeability medicine.drug_class Glucose uptake Glutamic Acid Glutamates Internal medicine medicine Animals Ketamine Molecular Biology Cells Cultured Cerebral Cortex Chemistry General Neuroscience Glutamate receptor Rats Inbred Strains Receptor antagonist Rats Endocrinology medicine.anatomical_structure Cell culture Astrocytes Anesthesia Neurology (clinical) Swelling medicine.symptom Intracellular Developmental Biology medicine.drug Astrocyte |
| Zdroj: | Brain Research. 487:380-383 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(89)90845-7 |
| Popis: | Effects of ketamine on glutamate-induced swelling of astrocytes in primary cell culture were studied. Following the exposure to 1 mM glutamate (Glu) for 4 h the intracellular water space (as measured by 3-O-methyl-[ 14 C]glucose uptake) of astrocytes was increased by two-fold concomitant with cell swelling and disappearance of cellular processed observed by phase-contrast microscopy. Ketamine, when co-incubated with Glu, reduced the astrocytic swelling in a dose-dependent manner. These data suggested that ketamine, in addition to its function as a non-comparative N-methyl- d -aspartate receptor antagonist, is also involved in protecting astrocytes from Glu-induced swelling. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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