Biomarkers and Cervical Length to Predict Spontaneous Preterm Birth in Asymptomatic High-Risk Women
| Autor: | Jamie A. Bastek, Suchitra Chandrasekaran, Meghan A. McShea, Laura Heiser, Brittany A. Araujo, Carter Owen, Adi Hirshberg, Michal A. Elovitz, Meghan E. Ryan |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
medicine.medical_specialty Fetal fibronectin Obstetrics business.industry Obstetrics and Gynecology Risk Assessment Asymptomatic Birth rate Cervical Length Measurement Pregnancy medicine Humans Premature Birth Biomarker (medicine) Gestation Female Prospective Studies medicine.symptom business Prospective cohort study Biomarkers Elafin |
| Zdroj: | Obstetrics & Gynecology. 122:283-289 |
| ISSN: | 0029-7844 |
| Popis: | OBJECTIVE To investigate whether biomarkers from different pathways of spontaneous preterm birth (cervical membrane degradation [fetal fibronectin], cervical remodeling [soluble E-cadherin], and inflammation (elafin, surfactant protein-D, interleukin-6 [IL-6]) were superior to one biomarker alone in predicting preterm birth. Our secondary objective was to examine the association of these biomarkers with cervical length in predicting preterm birth. METHODS We performed a single-center, prospective cohort study from August 2011 to November 2012 of asymptomatic women at risk for spontaneous preterm birth as a result of obstetric and gynecologic history. Cervicovaginal fluid and cervical length measurements were collected at two time points (20-23 6/7 weeks and 24-27 6/7 weeks of gestation). RESULTS Among the 104 women with complete data, the preterm birth rate was 24.5%. Prior preterm birth (P=.006) and cervical length at visit 1 (P=.003) were significantly associated with preterm birth, whereas fetal fibronectin and median biomarker levels (elafin, soluble E-cadherin, IL-6) were not. Median surfactant protein-D levels at visit 1 by preterm birth status were statistically but not clinically different (0.44 ng/mL compared with 0.40 ng/mL, P |
| Databáze: | OpenAIRE |
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