Serum zinc levels amongst under-five children with acute diarrhoea and bacterial pathogens
| Autor: | AO Saka, Sikiru Abayomi Biliaminu, Ayodele Ojuawo, Oyetundun Fausat Afolabi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Diarrhea
medicine.medical_specialty Klebsiella chemistry.chemical_element Nigeria Zinc medicine.disease_cause Gastroenterology Internal medicine medicine Humans Child biology Bacteria business.industry Pseudomonas aeruginosa Infant General Medicine Bacterial Infections medicine.disease biology.organism_classification Proteus chemistry Case-Control Studies Child Preschool Zinc deficiency Etiology Population study business |
| Zdroj: | The Nigerian postgraduate medical journal. 25(3) |
| ISSN: | 1117-1936 |
| Popis: | Background and Aim: Acute diarrhoea contributes significantly to morbidity and mortality in under-five children globally with conflicting reports regarding the therapeutic benefit of zinc across the different causative pathogens. This study aimed to determine the prevalence of bacterial aetiology of children with acute diarrhoea and compare their serum zinc levels. Methods: One hundred children aged 2–59 months with acute diarrhoea and 100 apparently healthy matched controls were recruited in Ilorin, North Central Nigeria. Stool specimens were investigated for bacterial pathogens using conventional culture techniques, while serum zinc levels were determined by colorimetric method. Results: Bacteria were isolated in 73 (73.0%) patients and 6 (6.0%) controls. Escherichia coli was isolated in 39 (39.0%) of the patients, while Klebsiella spp., Proteus spp. and Pseudomonas aeruginosa were isolated in 28 (28.0%), 4 (4.0%) and 2 (2.0%) patients, respectively.E. coli and Klebsiella spp. were detected in 4 (4.0%) and 2 (2.0%) controls, respectively. The mean serum zinc level of 65.3 ± 7.4 μg/dl in the patients was significantly lower than 69.0 ± 6.5 μg/dl in the controls (P < 0.001). Zinc deficiency (serum zinc levels < 65 μg/dl) was detected in 47 (47.0%) patients which was significantly higher than 32 (32.0%) controls (P = 0.030). The mean serum zinc levels significantly differed amongst the bacteria isolated in the patients (P < 0.001). Conclusions: Bacterial pathogens constitute a significant burden to aetiology of acute diarrhoea in under-five Nigerian children. The prevalence of zinc deficiency was high in the study population. The serum zinc levels also differed across the bacteria isolated. |
| Databáze: | OpenAIRE |
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