Gene nomenclature by default, or BLASTing to Babel
| Autor: | David R. Nelson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Subfamily
lcsh:QH426-470 cytochrome P450 Genetics Medical Genome Update orthologue lcsh:Medicine mouse genome Genome browser Biology Genome Mice Cytochrome P-450 Enzyme System Terminology as Topic Drug Discovery Genetics Animals Humans Gene family gene nomenclature Letter to the Editor Molecular Biology Nomenclature Gene Genome Human lcsh:R rat genome Human genetics Rats Gene nomenclature lcsh:Genetics Genetic Techniques Multigene Family Models Animal Molecular Medicine |
| Zdroj: | Human Genomics, Vol 2, Iss 3, Pp 196-201 (2005) Human Genomics |
| ISSN: | 1479-7364 |
| Popis: | The current proliferation of mammalian genomes is creating a nomenclature issue caused by naming genes based on their best BLAST hit to a gene in another annotated genome. The rat genome is relying heavily on the mouse genome for nomenclature, but not all rat genes have direct orthologues in the mouse; often, there are paralogous groups of genes -- due to expansions of that gene subfamily in one or the other genome. Many of these genes have already been assigned names in the rat, so that renaming them based on BLAST scores leads to duplicate sets of names. The supposed orthology created by name sharing across genomes is not always found. These inaccurate names are appearing in frequently used sites, such as the University of California Santa Cruz Genome Browser. The example of rat cytochrome P450 (Cyp) genes is presented here, but other gene families are also likely to be affected. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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