Sentinel surveillance for human enterovirus 71 in Sarawak, Malaysia: lessons from the first 7 years
| Autor: | Yuwana Podin, Mary Jane Cardosa, Thian-Yew Wee, Edna L M Gias, Siew-Fung Yee, Bibiana Teo, Yee-Wei Leong, Mohd Taha Arif, David Perera, Flora Ong, Andrew Kiyu, Sik-Chi Yao, Mohd Apandi Yusof, Sik-King Yao |
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| Jazyk: | angličtina |
| Předmět: |
Serotype
medicine.medical_specialty Genotype medicine.disease_cause Disease Outbreaks 03 medical and health sciences 0302 clinical medicine Species Specificity Epidemiology Humans Medicine 030212 general & internal medicine Serotyping Child Genotyping Phylogeny Enterovirus 030304 developmental biology 0303 health sciences Foot-and-mouth disease Reverse Transcriptase Polymerase Chain Reaction business.industry Transmission (medicine) lcsh:Public aspects of medicine Public health Malaysia Public Health Environmental and Occupational Health Outbreak lcsh:RA1-1270 medicine.disease Virology 3. Good health Child Preschool RNA Viral Hand Foot and Mouth Disease business Sentinel Surveillance Research Article |
| Zdroj: | BMC Public Health BMC Public Health, Vol 6, Iss 1, p 180 (2006) |
| ISSN: | 1471-2458 |
| DOI: | 10.1186/1471-2458-6-180 |
| Popis: | Background A major outbreak of human enterovirus 71-associated hand, foot and mouth disease in Sarawak in 1997 marked the beginning of a series of outbreaks in the Asia Pacific region. Some of these outbreaks had unusually high numbers of fatalities and this generated much fear and anxiety in the region. Methods We established a sentinel surveillance programme for hand, foot and mouth disease in Sarawak, Malaysia, in March 1998, and the observations of the first 7 years are described here. Virus isolation, serotyping and genotyping were performed on throat, rectal, vesicle and other swabs. Results During this period Sarawak had two outbreaks of human enterovirus 71, in 2000 and 2003. The predominant strains circulating in the outbreaks of 1997, 2000 and 2003 were all from genogroup B, but the strains isolated during each outbreak were genetically distinct from each other. Human enterovirus 71 outbreaks occurred in a cyclical pattern every three years and Coxsackievirus A16 co-circulated with human enterovirus 71. Although vesicles were most likely to yield an isolate, this sample was not generally available from most cases and obtaining throat swabs was thus found to be the most efficient way to obtain virological information. Conclusion Knowledge of the epidemiology of human enterovirus 71 transmission will allow public health personnel to predict when outbreaks might occur and to plan interventions in an effective manner in order to reduce the burden of disease. |
| Databáze: | OpenAIRE |
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