Diagnostic accuracy and prognostic value of the CD64 index in very low birth weight neonates as a marker of early-onset sepsis
| Autor: | Alice Zini, Antonio Regazzoli, Elena Garzoli, Gaetano Chirico, Mario Motta, Marinella Calarco, Luigi Caimi |
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| Rok vydání: | 2014 |
| Předmět: |
Microbiology (medical)
Male medicine.medical_specialty Pediatrics Multivariate analysis Newborn Sepsis Gestational Age Gastroenterology Internal medicine Medicine Humans Infant Very Low Birth Weight Prospective Studies Risk factor CD64 General Immunology and Microbiology Receiver operating characteristic business.industry Receptors IgG Infant Newborn General Medicine medicine.disease Prognosis Confidence interval Low birth weight Infectious Diseases ROC Curve Infant Extremely Low Birth Weight Relative risk Premature Birth Female medicine.symptom business Biomarkers |
| Zdroj: | Scandinavian journal of infectious diseases. 46(6) |
| ISSN: | 1651-1980 |
| Popis: | Objective: To assess the diagnostic and prognostic utility of CD64 expression as a marker of early-onset sepsis (EOS) in very low birth weight (VLBW) neonates. Methods: Neutrophil CD64 expression (CD64 index) was assessed in 129 VLBW neonates within 72 h after birth. The accuracy of the CD64 index in predicting EOS was determined by receiver operating characteristic curve analysis. The relationship between the expression of the CD64 index and neonatal outcomes was evaluated by multivariate analysis. Results: The highest performance of the CD64 index was achieved at 24 h after birth; accuracy, sensitivity, and negative predictive values were 0.85, 0.89, and 0.99, respectively, with a cut-off value of 2.4. The increased expression of CD64 index was significantly associated with subsequent infections (relative risk 1.54; 95% confidence interval 1.02–2.33). Conclusions: The CD64 index could be used as a reliable marker of EOS in VLBW neonates and it is an independent risk factor for late-onset infections. |
| Databáze: | OpenAIRE |
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