Hyaluronidase as additive to induction chemotherapy in advanced squamous cell carcinoma of the head and neck
| Autor: | H Sabitzer, S Wieser, J Schumer, W Raunik, J Klocker |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Cancer Research
medicine.medical_specialty Vindesine medicine.medical_treatment Hyaluronoglucosaminidase Gastroenterology Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Mucositis Humans Survival rate Chemotherapy business.industry Induction chemotherapy medicine.disease Surgery Survival Rate Oncology Epidermoid carcinoma Head and Neck Neoplasms Concomitant Vomiting Carcinoma Squamous Cell medicine.symptom Cisplatin business medicine.drug |
| Zdroj: | Cancer letters. 131(1) |
| ISSN: | 0304-3835 |
| Popis: | Forty-eight patients with advanced head and neck tumours were treated with irradiation and concomitant chemotherapy with cisplatin, vindesine and hyaluronidase. The disease-free survival rate at 5 years was 47%. The toxic effects were mucositis (48 patients), nausea (25 patients, vomiting in six patients), bone marrow depression (15 patients) and peripheral neuropathy (14 patients). The results warrant a randomized trial. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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