INTESTINAL METAPLASIA WITH COLONIC-TYPE SULPHOMUCINS IN THE GASTRIC MUCOSA; ITS ASSOCIATION WITH GASTRIC CARCINOMA
| Autor: | Matti Kekki, Lars Hjelt, K. Varis, T. Ihamäki, Max Siurala, Pentti Sipponen, K. Seppälä |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male High iron diamine Pathology medicine.medical_specialty Large population Gastric carcinoma Diamines Biology Gastroenterology 03 medical and health sciences Sex Factors 0302 clinical medicine Stomach Neoplasms Internal medicine Anemia Pernicious medicine Gastric mucosa Humans Aged pernicious anemia Metaplasia Staining and Labeling Endoscopic biopsy Age Factors Mucins Intestinal metaplasia General Medicine Middle Aged medicine.disease 3. Good health Intestines medicine.anatomical_structure Gastric Mucosa 030220 oncology & carcinogenesis Immunohistochemistry Female 030211 gastroenterology & hepatology Alcian Blue |
| Zdroj: | Acta Pathologica Microbiologica Scandinavica Section A Pathology. :217-224 |
| ISSN: | 0365-4184 |
| DOI: | 10.1111/j.1699-0463.1980.tb02489.x |
| Popis: | The occurrence of intestinal metaplasia with colonic-type sulphomucins: (abbreviated: s-IM or s-positive IM) in the gastric mucosa was studied in 125 patients with gastric carcinoma (GCA), 62 patients with pernicious anemia (PA), 301 and 183 first-degree relatives of GCA and PA patients, 406 outpatients and in 358 controls matched from a large population sample. The sulphomucins (s-mucins) were demonstrated histochemically in endoscopic biopsy specimens by using high iron diamine and Alcian blue (pH 1) methods. The prevalence of s-IM, especially the strongly s-positive IM, was significantly higher in GCA patients than in other series or controls of the same age group. Further, s-IM was significantly more common in PA patients and its prevalence higher in GCA relatives and outpatients than in other series or controls. The occurrence of s-IM was also age-dependent and dependent on the extent of IM. It was suggested that the occurrence of s-IM can be used as a sign of lesions that are more closely associated with GCA than IM is in general. |
| Databáze: | OpenAIRE |
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