Seven DNA polymorphisms at the candidate genes of atherosclerosis in Brazilian women with angiographically documented coronary artery disease
| Autor: | Rosario Dominguez Crespo Hirata, S D Giannini, Luis A. Salazar, Mario Hiroyuki Hirata, Thais Martins de Lima, Neusa Assumpta Forti, Jayme Diament |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Apolipoprotein E
medicine.medical_specialty Candidate gene Genotype Apolipoprotein B Arteriosclerosis Clinical Biochemistry Coronary Disease Coronary Angiography Biochemistry Genetic determinism Coronary artery disease Internal medicine medicine Humans Polymorphism Genetic biology Biochemistry (medical) DNA General Medicine Middle Aged medicine.disease Endocrinology Genetic marker biology.protein Female Brazil Lipoprotein |
| Zdroj: | Clinica Chimica Acta. 300:139-149 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/s0009-8981(00)00308-9 |
| Popis: | The possible association of genetic markers at the apolipoprotein E (HhaI polymorphism), apolipoprotein B (XbaI, EcoRI and Ins/Del polymorphisms), and low-density lipoprotein receptor (LDLR) (AvaII, HincII and PvuII polymorphisms) with coronary artery disease (CAD) was evaluated in 50 Brazilian women with CAD diagnosed by angiography and in 100 healthy women (controls). The frequency of E3/E4 genotype for HhaI polymorphism at the Apo E gene was significantly higher in CAD patients than in controls (40% vs. 14%, respectively, P |
| Databáze: | OpenAIRE |
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