Antitussive effects of nasal thymol challenges in healthy volunteers
| Autor: | Mariana Brozmanova, Jana Plevkova, Tomas Buday, Zuzana Biringerova, Silvia Gavliakova, Ivan Poliacek, V Calkovsky |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Physiology medicine.medical_treatment Provocation test Young Adult chemistry.chemical_compound Healthy volunteers medicine Humans Total count Thymol Saline Administration Intranasal business.industry General Neuroscience Normal lung function Healthy Volunteers respiratory tract diseases Antitussive Agents Cough chemistry Capsaicin Anesthesia Sensory System Agents Female Nasal administration business |
| Zdroj: | Respiratory Physiology & Neurobiology. 187:104-107 |
| ISSN: | 1569-9048 |
| DOI: | 10.1016/j.resp.2013.02.011 |
| Popis: | Eighteen healthy volunteers with normal lung function were tested for cough. Before and after nasal administration of thymol (0.025 ml, 10(-3) M) into both nostrils, urge-to-cough, cough threshold, cumulative and total count of coughs per provocation were estimated during standardized and validated capsaicin cough challenge. Nasal thymol challenges induced pleasant olfactory sensation and in 6 out of the 18 subjects also mild cooling sensation. Cough threshold was not influenced when compared with intranasal saline and vehicle challenges (12.5 vs. 13.2 vs. 10.2 μM of capsaicin to induce two or more coughs (C2), respectively), but the total count of coughs after nasal thymol challenge was significantly lower than that obtained after saline or vehicle (19 vs. 20 vs. 14 coughs/provocation, respectively; p |
| Databáze: | OpenAIRE |
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