In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease

Autor: Daniela Perani, Massimo Alessio, Valentina Garibotto, Sandro Iannaccone, G. Gelsomino, Chiara Cerami, Rosa Maria Moresco, Stefano Olivieri, Andrea Panzacchi
Přispěvatelé: Iannaccone, S, Cerami, C, Alessio, M, Garibotto, V, Panzacchi, A, Olivieri, S, Gelsomino, G, Moresco, R, Perani, D, M, Moresco R., Perani, DANIELA FELICITA L.
Rok vydání: 2012
Předmět:
Male
Pathology
medicine.medical_specialty
Parkinson's disease
Dementia/metabolism/pathology
Lewy bodies dementia
Disease
Microgliosis
medicine.disease_cause
ddc:616.0757
Diagnosis
Differential
03 medical and health sciences
0302 clinical medicine
Substantia Nigra/metabolism/pathology
medicine
Humans
Neuroimaging/methods
Pathological
Neuroinflammation
Aged
030304 developmental biology
Microglia activation
Aged
80 and over
0303 health sciences
Microglia
business.industry
Dementia with Lewy bodies
Microglia/metabolism/pathology
Parkinson Disease/metabolism/pathology
[11C]-PK11195
medicine.disease
3. Good health
Neurodegenerative Diseases/metabolism/pathology
medicine.anatomical_structure
PET
nervous system
Neurology
Brain/metabolism/pathology
Early Parkinson disease
Female
Neurology (clinical)
Geriatrics and Gerontology
Lewy Bodies/metabolism/pathology
business
030217 neurology & neurosurgery
Oxidative stress
Zdroj: Parkinsonism & Related Disorders
Parkinsonism & Related Disorders, Vol. 19, No 1 (2013) pp. 47-52
Parkinsonism & Related Disorders; Vol 19
Parkinsonism & related disorders 19 (2013): 47–52.
info:cnr-pdr/source/autori:S. Iannaccone; C. Cerami; M. Alessio;, Valentina Garibotto; Andrea Panzacchi; S. Olivieri; Giuliana Gelsomino; Rosa Maria Moresco; Daniela Perani./titolo:In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease/doi:/rivista:Parkinsonism & related disorders/anno:2013/pagina_da:47/pagina_a:52/intervallo_pagine:47–52/volume:19
ISSN: 1353-8020
Popis: Background: Reactive microgliosis, hallmark of neuroinflammation, may contribute to neuronal degeneration,as shown in several neurodegenerative diseases. We in vivo evaluated microglia activation inearly dementia with Lewy bodies, still not reported, and compared with early Parkinson’s disease, toassess possible differential pathological patterns. Methods: We measured the [11C]-PK11195 binding potentials with Positron Emission Tomography, usinga simplified reference tissue model, as marker of microglia activation, and cerebral spinal fluid proteincarbonylation levels, as marker of oxidative stress. Six dementia with Lewy bodies and 6 Parkinson’sdisease patients within a year from the onset, and eleven healthy controls were included. Clinicaldiagnosis was confirmed at a 4-year follow-up. Results: In dementia with Lewy bodies as well as in Parkinson’s disease, we found significant (p < 0.001)[11C]-PK11195 binding potential increases in the substantia nigra and putamen. Patients with Lewybodies dementia had extensive additional microglia activation in several associative cortices. This wasevident also at a single subject level. Significant increase of Cerebral Spinal Fluid proteincarbonizationwas shown in both patients’ groups. Conclusions: [11C]-PK11195 Positron Emission Tomography imaging revealed neuroinflammation indementia with Lewy bodies and Parkinson’s disease, mirroring, even at a single subject level, thecommon and the different topographical distribution of neuropathological changes, yet in the earlieststages of the disease process. Focusing on those events that characterize parkinsonisms and Parkinson’sdisease may be the key to further advancing the understanding of pathogenesis and to taking thesemechanisms forward as a means of defining targets for neuroprotection.
Databáze: OpenAIRE
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