Clinical features and diagnosis of hairy cell leukemia
| Autor: | James B. Johnston, Graeme R. Quest |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Proto-Oncogene Proteins B-raf Treatment response Pathology medicine.medical_specialty Indoles Clinical Biochemistry Mature B-Cell Lymphoproliferative disorders Antineoplastic Agents Diagnosis Differential Immunophenotyping Sex Factors Sex factors medicine Humans Hairy cell leukemia Fatigue B-Lymphocytes Leukemia Hairy Cell Sulfonamides Leukemia Prolymphocytic B-Cell business.industry Waldenstrom macroglobulinemia Lymphoma B-Cell Marginal Zone medicine.disease Oncology Vemurafenib Mutation Splenomegaly Splenectomy Female Differential diagnosis Waldenstrom Macroglobulinemia business |
| Zdroj: | Best practiceresearch. Clinical haematology. 28(4) |
| ISSN: | 1532-1924 |
| Popis: | Significant advances in the diagnosis and treatment of hairy cell leukemia (HCL) have recently been made. Improved distinction of HCL from its mimics though clinical presentations, morphologic and immunophenotypic features, and more recently molecular biology, has highlighted marked differences in treatment response and overall prognosis between these disorders. As our understanding of the unique pathobiology of HCL has grown, exciting new avenues of treatment as well as insight into immune function have been obtained. This review provides an overview of the clinical features and diagnostic attributes of HCL, with contrast to other mature B cell lymphoproliferative disorders with overlapping features. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect