Coronary artery- and aortic valve calcifications in patients with Philadelphia-negative myeloproliferative neoplasms
| Autor: | Camilla Nordheim Solli, Sandra Chamat-Hedemand, Hanne Elming, Anh Ngo, Lasse Kjær, Vibe Skov, Anders Lindholm Sørensen, Christina Ellervik, Andreas Fuchs, Per Ejlstrup Sigvardsen, Jørgen Tobias Kühl, Klaus Fuglsang Kofoed, Børge G. Nordestgaard, Hans Hasselbalch, Niels Eske Bruun |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Male
Aortic Valve Stenosis/diagnostic imaging Aortic valve disease Calcinosis Aortic Valve Stenosis Coronary Artery Disease Atherosclerosis Coronary artery disease Multidetector computed tomography Myeloproliferative disorders Aortic Valve/diagnostic imaging Cardiovascular diseases Risk Factors Aortic Valve Neoplasms Humans Female Cardiology and Cardiovascular Medicine Coronary Artery Disease/diagnostic imaging Aged |
| Zdroj: | Solli, C N, Chamat-Hedemand, S, Elming, H, Ngo, A, Kjær, L, Skov, V, Sørensen, A L, Ellervik, C, Fuchs, A, Sigvardsen, P E, Kühl, J T, Kofoed, K F, Nordestgaard, B G, Hasselbalch, H & Bruun, N E 2022, ' Coronary artery-and aortic valve calcifications in patients with Philadelphia-negative myeloproliferative neoplasms ', International Journal of Cardiology, vol. 364, pp. 112-118 . https://doi.org/10.1016/j.ijcard.2022.06.029 |
| Popis: | Background: Patients with the hematological cancers Philadelphia-negative Myeloproliferative Neoplasms (MPNs) have an increased risk of cardiovascular disease. However, whether MPNs have an increased burden of cardiac calcification has not been thoroughly investigated. Our aim is to investigate whether patients with MPNs have an increased burden of cardiac calcification that could help explain their increased risk of cardiovascular disease. Methods and results: We recruited 161 patients (mean age 65 years, 52% men) with an MPN diagnosis between 2016 and 2018. Coronary artery calcium score (CACS) and aortic valve calcification (AVC) were measured by cardiac computer tomography, and detailed information on cardiovascular risk factors was recorded. MPNs were matched on age and sex, with 805 controls from the Copenhagen General Population Study. A CACS>400 was present in 26% of MPNs and 19% of controls (p = 0.031). AVC was present in 58% of MPNs and 34% of controls (p < 0.0001). After adjustment for cardiovascular risk factors, the odds ratio (OR) of a CACS>400 was 1.9 (95% CI 1.2–3.1, p = 0.008) in MPNs compared to controls, and the OR of AVC was 4.4 (95% CI 2.9–6.9, p < 0.0001) in MPNs compared to controls. Conclusion: Patients with MPNs have a significantly higher prevalence of a CACS >400 and AVC, compared to controls from the general population. The association between MPN and a CACS>400 or AVC remains significant after adjustment for cardiovascular risk factors. These novel data support the hypothesis that MPNs have an increased burden of cardiac calcifications, independent of other cardiovascular risk factors. |
| Databáze: | OpenAIRE |
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