Synthesis and anabolic/androgenic evaluation of novel 9α-fluorosteroids
| Autor: | M. Reyes-Moreno, I. Rodeiro-Guerra, J. Sandoval Ramírez, I. Martínez-Hormaza, Y. Ibarra-Reyes, I. Hernández-Balmaseda, J.A. Ruiz-García, H. Vélez-Castro, S. Meza Reyes, Sara Montiel-Smith, Ariadna Fuente-Hernández |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Anabolism Stereochemistry medicine.medical_treatment Chemical synthesis Steroid Anabolic Agents Drug Discovery medicine Animals Rats Wistar Spectral data Pharmacology Chemistry Muscles Organic Chemistry Prostate Seminal Vesicles Biological activity Fluorine Organ Size General Medicine Carbon-13 NMR Rats Androgens Proton NMR Androstanes |
| Zdroj: | European Journal of Medicinal Chemistry. 44:4567-4571 |
| ISSN: | 0223-5234 |
| DOI: | 10.1016/j.ejmech.2009.06.025 |
| Popis: | 3Beta,11beta-dihydroxy-9alpha-fluor-5alpha-androstane-17-one (2), 3beta-acetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane-17-one (3), 3beta-acetoxy-9alpha-fluor-11beta,17beta-dihydroxy-5alpha-androstane (4), 3beta,17beta-diacetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane (5), 3beta-acetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane 17beta-propionate (6), 3beta-acetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane 17beta-enanthate (7), 3beta-acetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane 17beta-isobutyrate (8) were synthesized in the present study. Compounds 2 and 8 exhibited higher anabolic activity than the rest of the synthesized compounds. The structure of all these newly synthesized compounds was confirmed by analytic spectral data (mass, (1)H NMR and (13)C NMR). |
| Databáze: | OpenAIRE |
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