Pharmacokinetic considerations of oral chemotherapy in elderly patients with cancer
| Autor: | Stuart M. Lichtman, J. Andrew Skirvin |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Oncology
Complementary Therapies medicine.medical_specialty medicine.medical_treatment Population Administration Oral Antineoplastic Agents Pharmacology Hydroxycarbamide Pharmacotherapy Cytochrome P-450 Enzyme System Internal medicine Neoplasms medicine Temozolomide Humans Pharmacology (medical) education Antineoplastic Agents Alkylating Etoposide Aged Chemotherapy education.field_of_study business.industry Thalidomide Dacarbazine Tamoxifen Topotecan Geriatrics and Gerontology business Idarubicin medicine.drug |
| Zdroj: | Drugsaging. 19(1) |
| ISSN: | 1170-229X |
| Popis: | Persons over the age of 65 years are the fastest growing segment of the US population. In the next 30 years they will comprise over 20% of the population. Fifty per cent of all cancers occur in this age group and therefore there will be an expected rise in the total cancer burden. There has been an increasing trend over the past 20 years toward the use of oral chemotherapy. This change has been encouraged by the need to decrease the costs of chemotherapy administration, patient preferences and quality of life issues. Factors that must be considered with oral chemotherapy administration include limitations of saturability of absorption, patient compliance and pharmacokinetic/pharmacodynamic changes which occur in elderly patients. Interpatient variability and drug metabolism, particularly age-related changes in drug metabolism are being studied. The cytochrome P450 system has been intensively studied because of its importance with regard to chemotherapeutic drugs. This article reviews these issues and provides details regarding specific drugs including temozolomide, thalidomide, topotecan, the fluoropyrimidines, etoposide, hydroxycarbamide (hydroxyurea), tamoxifen, and alkylating drugs. Complementary and alternative therapies are also discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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