Asymptomatic Leishmania infection in blood donors from the Southern of Spain
| Autor: | Gemma Merino-Espinosa, Antonio Sampedro, Julian Ceballos, Joaquina Martín-Sánchez, Miguel Ángel López-Nevot, Francisco Morillas-Márquez, Fernando Cobo, Luis Aliaga |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) medicine.medical_specialty Livestock Adolescent Endemic Diseases Concordance 030106 microbiology Antibodies Protozoan Blood Donors Human leukocyte antigen Asymptomatic Serology Young Adult 03 medical and health sciences 0302 clinical medicine HLA Antigens Epidemiology medicine Animals Humans 030212 general & internal medicine Leishmania infantum Asymptomatic Infections Leishmaniasis Aged biology business.industry General Medicine DNA Protozoan Middle Aged Leishmania biology.organism_classification medicine.disease Infectious Diseases Spain Immunology biology.protein Female medicine.symptom Antibody business |
| Zdroj: | Infection. |
| ISSN: | 1439-0973 0300-8126 |
| Popis: | To investigate the proportion of asymptomatic infection among blood donors in a region endemic for Leishmania; and to ascertain epidemiological and genetic factors associated with this condition. We studied 1260 blood donors in the Province of Granada in the Southern Spain. After obtaining informed consent in each participant, a poll about habits, housing and contact with animals were carried out. Blood samples were obtained for determining antileishmanial antibodies and a PCR assay. HLA typing was performed in a randomly sample among the donors with positive serology. We have found that L. infantum antibodies were present in 7.9% of blood donors and DNA in blood was detected in 2.5% of donors. There was no concordance between both determinations, except in one patient. Taking into consideration both techniques, 129 participants were considered to have asymptomatic Leishmania infection. No participant in this study developed clinical leishmaniasis during a follow-up period of 2 years. HLA were typed in 51 donors. Asymptomatic Leishmania infection might be associated with certain HLA antigens. A multivariate analysis was done with the variables obtained through the participants’ interview. The contact with livestock (goats, pigs, and sheep), but not dogs, either at home or in the environment, was significantly and independently associated with asymptomatic leishmania infection. Asymptomatic leishmanial infection among blood donors is frequent in the Granada Province, south of Spain. The presence of livestock in this region is related to this infection, perhaps influencing vector density of this disease. Some HLA genes might be associated with asymptomatic leishmanial state. |
| Databáze: | OpenAIRE |
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