Indicators of the need for insulin treatment and the effect of treatment for gestational diabetes on pregnancy outcomes in Japan
| Autor: | Takashi Miyazaki, Yasuo Terauchi, Ryou Nagata, Takashi Mihara, Yoko Motoki, Shihou Ito, Hiromi Konishi, Saho Hosokawa, Yuzuru Ito, Tatsuya Matsunaga, Ken Sugiura, Yoshiyuki Nomura, Makoto Shibuya |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism 030204 cardiovascular system & hematology 03 medical and health sciences Hospitals Urban 0302 clinical medicine Endocrinology Japan Pregnancy Diabetes mellitus Diet Diabetic medicine Humans Hypoglycemic Agents Insulin Retrospective Studies Glycemic Family Health Glucose tolerance test Fetal Growth Retardation medicine.diagnostic_test business.industry Obstetrics Pregnancy Outcome Dietary management nutritional and metabolic diseases Glucose Tolerance Test medicine.disease Gestational diabetes Diabetes Gestational Low birth weight Hyperglycemia Multivariate Analysis Female medicine.symptom business |
| Zdroj: | Endocrine Journal. 63:231-237 |
| ISSN: | 1348-4540 0918-8959 |
| DOI: | 10.1507/endocrj.ej15-0427 |
| Popis: | This study assessed indicators of the need for insulin therapy and the effect of treatment on pregnancy outcomes in Japanese patients with gestational diabetes mellitus (GDM). All patients diagnosed with GDM were hospitalized for three days. Plasma glucose profiles in patients under strict dietary management and the characteristics of GDM patients with high daily glucose levels were investigated. Patients who failed to achieve glycemic targets were treated with insulin. Indicators of the need for insulin treatment were investigated. Pregnancy outcomes in patients prescribed dietary management and patients prescribed insulin treatment were compared. The study included 112 patients with GDM. GDM patients with high daily glucose levels in the hospital exhibited significantly higher 1-h and 2-h plasma glucose levels in oral glucose tolerance tests (OGTTs) at diagnosis. In our hospital, 102 GDM patients with singleton pregnancies were followed until delivery; 32 (31.3%) were treated with insulin. Univariate analysis identified significant associations of insulin requirement with family history of diabetes and with 1-h and 2-h OGTT values at diagnosis. Multivariate analysis showed that the 1-h OGTT plasma glucose level at diagnosis was an independent predictor of the need for insulin. In perinatal outcomes, insulin treatment was associated with low birth weight. |
| Databáze: | OpenAIRE |
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