Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke

Autor:	Wolfgang Omlor, Miriam Gullo, Jose C. Rubio, H. Zheng, J. L. Chen, Oliver Weinmann, K. Kobayashi, A. Schröter, Anna-Sophia Wahl, Martin E. Schwab, Fritjof Helmchen, Björn Ommer
Rok vydání:	2014
Předmět:	Multidisciplinary Rehabilitation Neurite business.industry medicine.medical_treatment Motor control medicine.disease Spinal cord medicine.anatomical_structure Corticospinal tract Forebrain Medicine Forelimb business Neuroscience Stroke
Zdroj:	Science
ISSN:	1095-9203 0036-8075
DOI:	10.1126/science.1253050
Popis:	Improving stroke recovery by timing treatment Patients recovering from strokes often fight a long uphill battle, with mixed results. Studying the effect of physical training on regeneration from damaged nerves in a model of stroke in rats, Wahl et al. show that timing matters. First, the researchers gave the rats a stroke, which damaged their ability to reach for food pellets with their forelimbs. The researchers then gave them physical training and treated them with an antibody to encourage neural regeneration. The rats improved more when the researchers waited until after the antibody treatment to start the training. Damaged circuits, it seems, need a little time to regrow before being called into action. Science , this issue p. 1250
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5b3b3191253245e6c88d34b94dd540 https://doi.org/10.1126/science.1253050 Zobrazit plný text záznamu Plný text ve formátu PDF