Children with Cerebral Palsy Hyper-Gate Somatosensory Stimulations of the Foot

Autor: Max J. Kurz, Alex I. Wiesman, Nathan M. Coolidge, Tony W. Wilson
Rok vydání: 2017
Předmět:
Male
medicine.medical_specialty
Time Factors
Adolescent
Cognitive Neuroscience
Sensory system
Audiology
Somatosensory system
Brain mapping
Functional Laterality
050105 experimental psychology
Cerebral palsy
Cohort Studies
Perceptual Disorders
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Neuroimaging
Image Processing
Computer-Assisted
medicine
Humans
0501 psychology and cognitive sciences
Cortical Synchronization
Child
Brain Mapping
Sensory gating
medicine.diagnostic_test
Foot
business.industry
Cerebral Palsy
05 social sciences
Magnetoencephalography
Gross Motor Function Classification System
Original Articles
Somatosensory Cortex
medicine.disease
Magnetic Resonance Imaging
medicine.anatomical_structure
Female
Tibial Nerve
business
030217 neurology & neurosurgery
Zdroj: Cerebral Cortex. :1-8
ISSN: 1460-2199
1047-3211
DOI: 10.1093/cercor/bhx144
Popis: We currently have a substantial knowledge gap in our understanding of the neurophysiological underpinnings of the sensory perception deficits often reported in the clinic for children with cerebral palsy (CP). In this investigation, we have begun to address this knowledge gap by using magnetoencephalography (MEG) brain imaging to evaluate the sensory gating of neural oscillations in the somatosensory cortices. A cohort of children with CP (Gross Motor Function Classification System II-III) and typically developing children underwent paired-pulse electrical stimulation of the tibial nerve during MEG. Advanced beamforming methods were used to image significant oscillatory responses, and subsequently the time series of neural activity was extracted from peak voxels. Our experimental results showed that somatosensory cortical oscillations (10-75 Hz) were weaker in the children with CP for both stimulations. Despite this reduction, the children with CP actually exhibited a hyper-gating response to the second, redundant peripheral stimulation applied to the foot. These results have further established the nexus of the cortical somatosensory processing deficits that are likely responsible for the degraded sensory perceptions reported in the clinic for children with CP.
Databáze: OpenAIRE
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