In vivo metabolism of diallyl disulphide in the rat : identification of two new metabolites
| Autor: | Marie-Hélène Siess, Jacques Auger, Caroline Teyssier, E. Germain, C. Ginies |
|---|---|
| Přispěvatelé: | Unité mixte de recherche de toxicologie alimentaire, Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA), Centre National de la Recherche Scientifique (CNRS), FLAveur, VIsion et Comportement du consommateur (FLAVIC), Etablissement National d'Enseignement Supérieur Agronomique de Dijon (ENESAD)-Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB) |
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Male
Time Factors Health Toxicology and Mutagenesis Administration Oral Urine Toxicology Biochemistry GARLIC 0302 clinical medicine Oral administration Spectroscopy Fourier Transform Infrared Tissue Distribution Disulfides Anticarcinogen Mesylates 0303 health sciences Chemistry DADS food and beverages General Medicine 3. Good health Allyl Compounds in vivo 030220 oncology & carcinogenesis SULFUR COMPOUND XENOBIOTIC METABOLISM RAT ail composé soufre xénobiotique [SDV.BID]Life Sciences [q-bio]/Biodiversity Sulfides Gas Chromatography-Mass Spectrometry Excretion 03 medical and health sciences In vivo Animals Humans Rats Wistar métabolisme 030304 developmental biology Pharmacology Chromatography Metabolism Sulfinic Acids Rats Models Chemical Allyl Mercaptan Gas chromatography |
| Zdroj: | Xenobiotica Xenobiotica, Taylor & Francis, 2002, 32 (12), pp.1127-1138. ⟨10.1080/0049825021000017902⟩ Xenobiotica 12 (32), 1127-1138. (2002) |
| ISSN: | 0049-8254 1366-5928 |
| DOI: | 10.1080/0049825021000017902⟩ |
| Popis: | International audience; 1. Diallyl disulphide (DADS), a compound formed from the organosulphur compounds present in garlic, is known for its anticarcinogenic effects in animal models. 2. The aim was to identify and analyse the metabolites produced in vivo after a single oral administration of 200 mg kg -1 DADS to rats. The organic sulphur metabolites present in the stomach, liver, plasma and urine were measured by gas chromatography coupled with mass spectrometry over 15 days. 3. Data indicate that DADS is absorbed and transformed into allyl mercaptan, allyl methyl sulphide, allyl methyl sulphoxide (AMSO) and allyl methyl sulphone (AMSO 2 ), which are detected throughout the excretion period. Overall, the highest amounts of metabolites were measured 48-72h after the DADS administration. AMSO 2 is the most abundant and persistent of these compounds. The levels of all the sulphur compounds rapidly decline within the first week after administration and disappear during the second week. Only AMSO and AMSO 2 are significantly excreted in urine. 4. These potential metabolites are thought to be active in the target tissues. Our data warrant further studies to check this hypothesis. |
| Databáze: | OpenAIRE |
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