Early Clinical Experience with a Polymer-Free Biolimus A9 Drug-Coated Stent in DES-Type Patients Who Are Poor Candidates for Prolonged Dual Anti-Platelet Therapy

Autor: Anirban Choudhury, Richard Anderson, Tim Kinnaird, Sean Gallagher, Mehmood Butt, Khaled Yazji, Nicholas Ossei-Gerning, Ahmed Hailan, Fairoz Abdul, Alexander Chase, David R. Smith
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Male
Cardiovascular Procedures
medicine.medical_treatment
Myocardial Infarction
lcsh:Medicine
Coronary Artery Disease
030204 cardiovascular system & hematology
Cardiovascular Medicine
Pathology and Laboratory Medicine
Antiplatelet Therapy
Vascular Medicine
0302 clinical medicine
Restenosis
Risk Factors
Medicine and Health Sciences
Medicine
030212 general & internal medicine
Prospective Studies
Prospective cohort study
lcsh:Science
Aged
80 and over

Multidisciplinary
Framingham Risk Score
Pharmaceutics
Drug-Eluting Stents
Hematology
Middle Aged
Treatment Outcome
Cardiovascular Diseases
Cohort
Platelet aggregation inhibitor
Drug Therapy
Combination

Female
Research Article
medicine.medical_specialty
Coronary Stenting
Cardiology
Hemorrhage
Surgical and Invasive Medical Procedures
03 medical and health sciences
Signs and Symptoms
Percutaneous Coronary Intervention
Drug Therapy
Diagnostic Medicine
Humans
Propensity Score
Blood Coagulation
Aged
Sirolimus
Coagulation Disorders
Aspirin
business.industry
lcsh:R
Stent
Percutaneous coronary intervention
Thrombosis
medicine.disease
Surgery
Stent Implantation
Lesions
lcsh:Q
business
Platelet Aggregation Inhibitors
Kidney disease
Zdroj: PLoS ONE, Vol 11, Iss 6, p e0157812 (2016)
PLoS ONE
ISSN: 1932-6203
Popis: Introduction Prolonged dual anti-platelet therapy (DAPT) may cause excess bleeding in certain patients. The biolimus-A9 drug-coated stent (BA9-DCS) has a rapid drug-elution profile allowing shortened DAPT. Data were gathered on the early experience implanting this stent in drug-eluting stent eligible patients deemed to be at high risk of bleeding. Background and Methods The demographics, procedural data and clinical outcomes were gathered prospectively for 249 patients treated with a BA9-DCS stent at 2 UK centres, and compared to a cohort of patients treated in the same period with drug-eluting stents (PCI-DES). Results Operator-defined BA9-DCS indications included warfarin therapy, age, and anaemia. Patients receiving a BA9-DCS were older (71.6±11.8 vs. 64.8±11.6yrs, p
Databáze: OpenAIRE