Association between serum levels of glutamate and neurotrophic factors and response to clozapine treatment
| Autor: | Abraham Weizman, Michal Taler, Amir Krivoy, Sarah Hollander, Yael Vilner, Mirjana Selaković, Kyra-Verena Sendt, Eldar Hochman |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Psychosis Glutamic Acid Enzyme-Linked Immunosorbent Assay Statistics Nonparametric 03 medical and health sciences 0302 clinical medicine Neurotrophic factors Internal medicine Glial cell line-derived neurotrophic factor medicine Humans Nerve Growth Factors Clozapine Biological Psychiatry Psychiatric Status Rating Scales Brain-derived neurotrophic factor biology Glutamate receptor Middle Aged medicine.disease 030227 psychiatry Psychiatry and Mental health Cross-Sectional Studies Endocrinology Schizophrenia Anesthesia biology.protein Female Psychology 030217 neurology & neurosurgery Antipsychotic Agents Neurotrophin medicine.drug |
| Zdroj: | Schizophrenia Research. 192:226-231 |
| ISSN: | 0920-9964 |
| Popis: | Clozapine is the only available therapy for about 30% of schizophrenia patients otherwise refractory to antipsychotics. Unfortunately, the mechanism of action of the drug is still unknown and there are no biomarkers that can predict a positive response to clozapine. We aimed to examine serum neurotrophins and glutamate levels as putative biomarkers for clozapine response based on the hypothesized mode-of-action of the compound. Blood samples of 89 chronic schizophrenia patients maintained on clozapine were analyzed in a cross-sectional design. Serum brain derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), neurotrophic growth factor (NGF), glial derived neurotrophic factor (GDNF) and glutamate were determined. Differences between responders and non-responders to clozapine and correlation between clinical and biological measures were analyzed. Our sample consisted of 54 (61%) responders and 35 (39%) non-responders. Responders had higher mean BDNF levels than non-responders (2066±814 vs. 1668±820pg/ml, p |
| Databáze: | OpenAIRE |
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