Migration studies of 3-chloro-1,2-propanediol (3-MCPD) in polyethylene extrusion-coated paperboard food packaging

Autor:	Thomas G. Hartman, Gregory V Pace
Rok vydání:	2010
Předmět:	Glycerol Paper Food contact materials business.product_category Health Toxicology and Mutagenesis alpha-Chlorohydrin Toxicology Gas Chromatography-Mass Spectrometry chemistry.chemical_compound 3-MCPD Vegetables Animals Humans Epichlorohydrin Food science Paperboard Chemistry Public Health Environmental and Occupational Health Alpha-Chlorohydrin Food Packaging Soy Foods General Chemistry General Medicine Food Analysis Carton Rats Food packaging visual_art visual_art.visual_art_medium Carcinogens business Food Science
Zdroj:	Food additivescontaminants. Part A, Chemistry, analysis, control, exposurerisk assessment. 27(6)
ISSN:	1944-0057
Popis:	The manufacturing process of paperboard food packaging can produce small quantities of 3-chloro-1,2-propanediol (3-MCPD or 3-monochloropropane-1,2-diol) when wet-strength resins containing epichlorohydrin are used. 3-MCPD is from the same family as 1,3-dichloro-2-propanol (1,3-DCP), which is known to cause cancer in animals. 3-MCPD has been found in acid hydrolyzed vegetable protein, Asian sauces and paperboard for food contact. In this investigation, we conducted extraction studies to measure 3-MCPD migration into food simulant solvents from the food contact side of polyethylene extrusion-coated paperboard beverage cartons and aqueous extractions of cut pieces from the entire paperboard. We demonstrate that 3-MCPD confirmed present at concentrations up to 9.9 mg kg(-1) within the paperboard matrix does not migrate through the polyethylene-coated food contact surface. The aqueous extraction of the entire paperboard and food contact side extractions with aqueous/acidic food simulants were performed using US Food and Drug Administration (FDA) and European Commission (EU) migration testing protocols. We also show that no significant amount of 3-MCPD migrates through the unskived edges on the inside seam of the paperboard structure. The methodology for the aqueous and migration cell extractions using GC-MS analyses was validated with a limit of quantification (LOQ) of 0.009 mg kg(-1) and a limit of detection (LOD) of 0.005 mg kg(-1).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e50d503553fb2623268629062948e69 https://pubmed.ncbi.nlm.nih.gov/20486004 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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