Are genetic polymorphisms of tumour necrosis factor alpha, interleukin-10, CD14 endotoxin receptor or manganese superoxide dismutase associated with alcoholic liver disease?

alanine. METHODS We sought confirmatory evidence, through individual and simultaneous analysis of the four aforementioned polymorphisms, in 176 heavy drinkers: ALD (n = 100) if histology-compatible or clinical evidence of hepatic decompensation; and no evidence of liver disease (NLD) (n = 76) if normal liver tests on two occasions or normal liver histology (steatosis alone). RESULTS Patients with ALD were older (53+/-10 vs. 48+/-10 years, P -->

ISSN:	0954-691X
Přístupová URL adresa:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4ebb26f3f51cae4ab5815f496c0994 https://pubmed.ncbi.nlm.nih.gov/16148556
Přírůstkové číslo:	edsair.doi.dedup.....4e4ebb26f3f51cae4ab5815f496c0994
Autor:	Alexandra Martins, Maria Sara Gonçalves, Pedro Marques-Vidal, Miguel Carneiro de Moura, Steffensen Soren, Helena Cortez-Pinto, Maria Ermelinda Camilo, Mariana V. Machado
Rok vydání:	2005
Předmět:	Adult Male medicine.medical_specialty Alcoholic liver disease Pathology Necrosis Alcohol Drinking Lipopolysaccharide Receptors Superoxide dismutase Liver disease Internal medicine Medicine Humans Genetic Predisposition to Disease Allele Liver Diseases Alcoholic Polymorphism Genetic Hepatology biology business.industry Superoxide Dismutase Tumor Necrosis Factor-alpha Gastroenterology Heterozygote advantage Middle Aged medicine.disease Interleukin-10 Interleukin 10 Endocrinology biology.protein Female medicine.symptom Steatosis business
Zdroj:	European journal of gastroenterologyhepatology. 17(10)
ISSN:	0954-691X
Popis:	BACKGROUND Four polymorphisms have been described associated with either increased risk for alcoholic liver disease (ALD) or more serious histological lesions: tumour necrosis factor alpha (TNF-alpha) G(-238)A, interleukin-10 (IL-10) C(-627)A, promoter of CD14 endotoxin receptor gene C(-159)T and manganese superoxide dismutase (MnSOD) C(-1183)T/valine --> alanine. METHODS We sought confirmatory evidence, through individual and simultaneous analysis of the four aforementioned polymorphisms, in 176 heavy drinkers: ALD (n = 100) if histology-compatible or clinical evidence of hepatic decompensation; and no evidence of liver disease (NLD) (n = 76) if normal liver tests on two occasions or normal liver histology (steatosis alone). RESULTS Patients with ALD were older (53+/-10 vs. 48+/-10 years, P
Databáze:	OpenAIRE
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