Episodic Molecular Evolution of Pituitary Growth Hormone in Cetartiodactyla
| Autor: | Michael Wallis, O. Caryl Wallis, Zoitsa Maniou |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Molecular Sequence Data
Evolution Molecular Exon Molecular evolution biology.animal Genetics Animals Cluster Analysis media_common.cataloged_instance Amino Acid Sequence Molecular Biology Gene Phylogeny Ecology Evolution Behavior and Systematics Artiodactyla DNA Primers media_common Base Composition Base Sequence biology Intron Sequence Analysis DNA biology.organism_classification Hippopotamus amphibius genomic DNA Gene Components Evolutionary biology Growth Hormone Hippopotamus Cetacea Sequence Alignment Giraffa camelopardalis |
| Zdroj: | Journal of Molecular Evolution. 58:743-753 |
| ISSN: | 1432-1432 0022-2844 |
| DOI: | 10.1007/s00239-004-2595-x |
| Popis: | The sequence of growth hormone (GH) is generally strongly conserved in mammals, but episodes of rapid change occurred during the evolution of primates and artiodactyls, when the rate of GH evolution apparently increased substantially. As a result the sequences of higher primate and ruminant GHs differ markedly from sequences of other mammalian GHs. In order to increase knowledge of GH evolution in Cetartiodactyla (Artiodactyla plus Cetacea) we have cloned and characterized GH genes from camel (Camelus dromedarius), hippopotamus (Hippopotamus amphibius), and giraffe (Giraffa camelopardalis), using genomic DNA and a polymerase chain reaction technique. As in other mammals, these GH genes comprise five exons and four introns. Two very similar GH gene sequences (encoding identical proteins) were found in each of hippopotamus and giraffe. The deduced sequence for the mature hippopotamus GH is identical to that of dolphin, in accord with current ideas of a close relationship between Cetacea and Hippopotamidae. The sequence of camel GH is identical to that reported previously for alpaca GH. The sequence of giraffe GH is very similar to that of other ruminants but differs from that of nonruminant cetartiodactyls at about 18 residues. The results demonstrate that the apparent burst of rapid evolution of GH occurred largely after the separation of the line leading to ruminants from other cetartiodactyls. |
| Databáze: | OpenAIRE |
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