Acute pancreatitis in Chile: A multicenter study on epidemiology, etiology and clinical outcome. Retrospective analysis of clinical files
| Autor: | Sergio Ledesma, Rodrigo Cruz, Eduardo Tobar, María Paz Morales, Carla Mancilla, Armando Sierralta, Mauricio Carrasco, Luis Godoy, Christián Lara, Eliana Valdés, Michel Baró, Zoltán Berger, Gustavo Ramirez, Julián Cordero, Ricardo Cruz |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism macromolecular substances Young Adult Internal medicine Epidemiology medicine Retrospective analysis Humans Chile Aged Retrospective Studies Aged 80 and over Hepatology business.industry Gastroenterology Mean age Middle Aged medicine.disease Pancreatitis Multicenter study Etiology Acute pancreatitis Female Observational study business |
| Zdroj: | Pancreatology. 20:637-643 |
| ISSN: | 1424-3903 |
| Popis: | Background Epidemiology of acute pancreatitis (AP) is variable in different geographical regions. Objectives To compare etiology and severity of AP to published data from South America and the rest of world, study impact of demographical factors and treatment on its outcome in Chilean hospitals. Methods Multicenter observational study. Data of consecutive patients with AP were collected at the moment of discharge from 11 centers and retrospectively analyzed. Results Data of 962 patients were included in the analysis, 447 men and 515 women. Mean age was 48,2 years. Biliary etiology was significantly more frequent in women (70%) than in men (52%). Conversely, alcohol was responsible for about 17% of AP in men but exceptional in women. Mild AP was seen in 73.4%, moderately severe in 14.1% and severe in 13%. The overall mortality was 2.5% (24 of 962): 0.3%, 3.1% and 15.1% in mild, moderately severe and severe cases, respectively. No difference was found in the mortality and severity of biliary versus alcoholic AP, while h ypertriglyceridemia induced AP was more severe, without increased mortality. Severity and mortality increased with age. ERCP was performed in 16% of biliary pancreatitis. Adherence to main guidelines was heterogeneous: more than half of mild AP patients were admitted to critical care units and antibiotics were used in about 25% them. Conclusion This is the first multicenter study in Chile on AP. When compared to literature, we found similar severity distribution and an acceptably low mortality. Biliary etiology was dominant, but alcohol was also important in men. |
| Databáze: | OpenAIRE |
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