Frequency of oral mucosa micronuclei in gas station operators after introducing methanol
| Autor: | Gilka Jorge Fígaro Gattás, Marcília de Araújo Medrado-Faria, P H Saldanha, Lais de Almeida Cardoso |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Alcohol fuel Analysis of Variance Mouth Ethanol Methanol Mouth Mucosa Public Health Environmental and Occupational Health Middle Aged chemistry.chemical_compound Petroleum Animal science chemistry Fuel gas Occupational Exposure Micronucleus test Toxicity Solvents Humans Regression Analysis Motor fuel Gasoline Brazil Micronuclei Chromosome-Defective |
| Zdroj: | Occupational Medicine. 51:107-113 |
| ISSN: | 1471-8405 0962-7480 |
| DOI: | 10.1093/occmed/51.2.107 |
| Popis: | Methanol has been proposed in different countries as an alternative automotive fuel to be used as an additive to, or replacement for, gasoline or ethanol. Utilization of methanol is increasing exposure to low levels of methanol vapors in the environment and more specifically in occupational settings such as gas stations. Pump operators are exposed to relatively high levels of fuel vapors, the consequences of which have not been fully examined. In this study, the micronucleus assay in squamous oral cells was performed on pump operators of 28 gas stations in three different periods in the city of São Paulo, Brazil. The frequency of micronuclei (MN) was evaluated before and 1 year after a mixed fuel called MEG, which contains 33% methanol, 60% ethanol and 7% gasoline, was introduced. The third evaluation, 3 years later, represents a period where the number of cars using alcohol fuel had decreased drastically and the pump operator exposure to MEG became very low. The frequency of MN observed in 76 employees in 1992 (mean = 3.62 +/- 0.39) was significantly increased (P0.001) as compared with 76 operators exposed in 1989 (mean = 1.41 +/- 0.26) and 129 exposed in 1995 (mean = 1.20 +/- 0.15). These differences were also significant when compared with control groups not exposed professionally to motor fuel. These findings could indicate a mutagenic hazard of the MEG occurring in those with occupational exposure. |
| Databáze: | OpenAIRE |
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