Characterization of the Sublimation and Vapor Pressure of 2-(2-Nitrovinyl) Furan (G-0) Using Thermogravimetric Analysis: Effects of Complexation with Cyclodextrins
| Autor: | Danny Winant, Guy Van den Mooter, Mirtha Mayra González, Zenaida Rodríguez, Vivian Ruz |
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| Rok vydání: | 2015 |
| Předmět: |
Thermogravimetric analysis
Time Factors Vinyl Compounds Vapor pressure Enthalpy Analytical chemistry Pharmaceutical Science thermogravimetry Isothermal process Article Analytical Chemistry lcsh:QD241-441 lcsh:Organic chemistry Drug Discovery Spectroscopy Fourier Transform Infrared Physical and Theoretical Chemistry Furans 2-(2-nitrovinyl) furan Cyclodextrins vapor pressure Calorimetry Differential Scanning Chemistry Organic Chemistry beta-Cyclodextrins Temperature sublimation enthalpy 2-Hydroxypropyl-beta-cyclodextrin Thermogravimetry Freeze Drying Chemistry (miscellaneous) Melting point Molecular Medicine Regression Analysis Sublimation (phase transition) Eyring equation |
| Zdroj: | Molecules Molecules, Vol 20, Iss 8, Pp 15175-15191 (2015) Volume 20 Issue 8 Pages 15175-15191 |
| ISSN: | 1420-3049 |
| Popis: | In the present work, the sublimation of crystalline solid 2-(2-nitrovinyl) furan (G-0) in the temperature range of 35 to 60 °C (below the melting point of the drug) was studied using thermogravimetric analysis (TGA). The sublimated product was characterized using Fourier-transformed-infrared spectroscopy (FT-IR) and thin layer chromatography (TLC). The sublimation rate at each temperature was obtained using the slope of the linear regression model and followed apparent zero-order kinetics. The sublimation enthalpy from 35 to 60 °C was obtained from the Eyring equation. The Gückel method was used to estimate the sublimation rate and vapor pressure at 25 °C. Physical mixtures, kneaded and freeze-dried complexes were prepared with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and sulfobutyl ether-β-cyclodextrin (SBE-β-CD) and analyzed using isothermal TGA at 50 °C. The complexation contributed to reducing the sublimation process. The best results were achieved using freeze-dried complexes with both cyclodextrins. ispartof: Molecules vol:20 issue:8 pages:15175-1591 ispartof: location:Switzerland status: published |
| Databáze: | OpenAIRE |
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