HCV and HEV: two players in an Egyptian village, a study of prevalence, incidence, and co-infection
| Autor: | Ferial El-Kalla, Loai Mansour, Lobna Abo-Ali, Ibrahim Kabbash, Abdelrahman Kobtan, Abdel-Raouf Abo-ElAzm, Sherief Atia, Sherief Abd-Elsalam, Gamal Esmat, Mohammed Elhendawy, Maha M Hagras |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Cirrhosis Carcinoma Hepatocellular Epidemiology Health Toxicology and Mutagenesis Hepatitis C virus Hepacivirus 010501 environmental sciences medicine.disease_cause Chronic liver disease 01 natural sciences Liver disease Hepatitis E virus Internal medicine medicine Prevalence Environmental Chemistry Humans Prospective Studies Prospective cohort study 0105 earth and related environmental sciences Aged business.industry Coinfection Incidence (epidemiology) Incidence Liver Neoplasms virus diseases General Medicine medicine.disease Pollution Hepatitis C digestive system diseases HEV HCV Egypt business Research Article |
| Zdroj: | Environmental Science and Pollution Research International |
| ISSN: | 1614-7499 |
| Popis: | The highest recorded hepatitis C virus (HCV) prevalence worldwide is in Egypt. A high prevalence of hepatitis E virus (HEV) in chronic liver disease has been reported. The aim of this study was to study prevalence, incidence, and outcome of HCV infection in an Egyptian Nile Delta village and the relation between HEV infection and HCV-related chronic hepatic affection. This prospective cohort study included 2085 Nagreej village residents. Mass HCV screening was conducted and testing for HEV antibodies among HCV-infected patients performed. The annual incidence of HCV was recorded. Five hundred five (24.22%) of the tested villagers were positive for HCV RNA. Prevalence escalated with age and male sex. The main recorded risk factors were a history of surgery, dental procedures, hospitalization, blood transfusion, and antischistosomal treatment. HEV IgG antibody was positive in 71.4% of individuals with chronic HCV and 96.1% with advanced liver disease (cirrhosis ± hepatocellular carcinoma (HCC)). After 1 year, 29 of the 1390 HCV Ab negative villagers had a positive HCV PCR, placing an annual incidence of new HCV infections at 2.09%. The Egyptian HCV prevalence remains high with infection particularly among the elderly. The annual incidence in a small Nile Delta village is 2.086%. HCV-HEV co-infection may lead to a worse prognosis among Egyptians with chronic liver disease. Electronic supplementary material The online version of this article (10.1007/s11356-020-09591-6) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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