Surgical and multimodality treatment of cardiac sarcomas: A systematic review and meta‐analysis

Autor:	Robert Vardanyan, Aleksandra Lopuszko, Alexander Weymann, Marcin Szczechowicz, Jef Van den Eynde, Alina Zubarevich, Arian Arjomandi Rad, Saeed Torabi, Michel Pompeu Barros de Oliveira Sá
Rok vydání:	2021
Předmět:	Pulmonary and Respiratory Medicine medicine.medical_specialty Medizin MEDLINE 030204 cardiovascular system & hematology Heart Neoplasms 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine Prospective Studies business.industry Multimodality Treatment Significant difference Sarcoma Combined Modality Therapy humanities Conservative treatment 030228 respiratory system Meta-analysis Resection margin Surgery Observational study Cardiology and Cardiovascular Medicine business Lower mortality
Zdroj:	Journal of Cardiac Surgery. 36:2476-2485
ISSN:	1540-8191 0886-0440
DOI:	10.1111/jocs.15538
Popis:	Introduction Primary cardiac sarcomas (PCSs) are an extremely rare and aggressive type of malignancies that have been described only by a limited number of observational studies. This study aimed to evaluate the currently existing evidence comparing surgical to multimodality treatment of PCS. Methods We systematically reviewed Embase, MEDLINE, Cochrane Database, and Google Scholar, from inception to December 2020, for original articles about surgical and multimodality treatment of PCS. The outcomes included were mortality at various time points, resection margin status, and mean estimated survival. The pooled treatment effects were calculated using a random-effects model. Results Ten studies including a total of 1570 patients met our inclusion criteria. Surgery was associated with significantly lower mortality when compared to conservative treatment at 1, 2, and 3 years, whereas no significant difference was found at 5 years. Furthermore, multimodality treatment showed significantly lower mortality at 1 year when compared to surgery alone, but not at 2 and 5 years. We found no difference in mortality between angiosarcomas and other PCS subtypes. Conclusion Overall, surgery was found to provide a significant mortality advantage to PCS patients up to 3 years following treatment. Multimodality treatment might be of additional benefit, although only within the first year. Prospective randomized studies are needed to further explore these differences in the treatment of PCS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4824ed83d6d97af744692493e24ed8 https://doi.org/10.1111/jocs.15538 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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