Identification of two antigenically and genetically distinct lineages of H3N8 equine influenza virus in Sweden
| Autor: | T Fridberger, Leif Oxburgh, B. Klingeborn, L Akerblom, Tommy Linné |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Serotype
Endemic Diseases Epidemiology Lineage (evolution) Orthomyxoviridae Molecular Sequence Data Equine influenza Biology medicine.disease_cause Virus Influenza A Virus H3N8 Subtype Gene Frequency Orthomyxoviridae Infections Influenza A virus medicine Animals Horses Serotyping Phylogeny Genetics Sweden Molecular epidemiology Base Sequence Strain (biology) biology.organism_classification Virology United States Europe Infectious Diseases Hemagglutinins DNA Viral Horse Diseases Research Article |
| Zdroj: | Epidemiology and infection. 120(1) |
| ISSN: | 0950-2688 |
| Popis: | Four Swedish strains of equine H3N8 influenza virus isolated from outbreaks during the last 4 years were characterized. Antigenic typing using monoclonal antibodies raised against a variety of H3N8 strains showed that the viruses are heterogeneous, the 1993 isolate being closely related to the 1991 Swedish isolate TAB/91 and the other three isolates from 1994 and 1996 being more closely related to each other. This pattern is reflected in the phylogenetic data calculated from nucleotide sequencing of the haemagglutinin genes. H3N8 equine influenza can be seen to be evolving in two distinct lineages, one European and one American. The 1993 isolate is closely related to the European lineage and is the most recent Swedish strain of this lineage to be isolated. The 1994 and 1996 isolates fit into the American lineage, which contains recent isolates from the United States and also Britain. These results indicate that American-type H3N8 viruses have become endemic in Sweden and, in light of the antigenic differences which can be observed between viruses belonging to the two lineages, we believe that equine influenza virus vaccines should be updated with an American-type virus strain. |
| Databáze: | OpenAIRE |
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