Voxel-wise correlations between cognition and cerebral blood flow using arterial spin-labeled perfusion MRI in patients with Alzheimer’s disease: a cross-sectional study
| Autor: | Ayako Shihikura-Hino, Tomio Inoue, Yoshio Hirayasu, Omi Katsuse, Tomohiro Kaneta, Toshinari Odawara, Keisuke Yoshida, Matsuyoshi Ogawa, Takamasa Hirano |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Pathology medicine.medical_specialty Neurology Cerebral arteries Perfusion scanning Superior parietal lobule computer.software_genre lcsh:RC346-429 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Voxel Cortex (anatomy) Internal medicine mental disorders Single Photon Emission Compute Tomography Image Processing Computer-Assisted Cerebral Blood Flow Image Humans Medicine Cognitive Dysfunction Default mode network lcsh:Neurology. Diseases of the nervous system Aged Aged 80 and over business.industry Default Mode Network General Medicine Magnetic Resonance Imaging Cerebral Blood Flow Cross-Sectional Studies medicine.anatomical_structure Cerebral blood flow nervous system Cerebrovascular Circulation Cardiology Female Spin Labels Neurology (clinical) Posterior Cingulate Cortex business computer 030217 neurology & neurosurgery Research Article |
| Zdroj: | BMC Neurology, Vol 17, Iss 1, Pp 1-9 (2017) BMC Neurology |
| ISSN: | 1471-2377 |
| DOI: | 10.1186/s12883-017-0870-x |
| Popis: | Background To analyze voxel-wise correlation between cerebral blood flow (CBF) measured using ASL-MRI and cognition in patients with Alzheimer’s disease (AD). Methods Forty-one patients diagnosed with AD or mild cognitive impairment due to AD were recruited for this study. CBF images were obtained using ASL-MRI (n = 41) with a post-labeling delay (PLD) of 1.5 and 2.5 s (PLD1.5 and PLD2.5, respectively) using a 3 T scanner, in addition to brain perfusion SPECT with N-isopropyl-4-[I-123]iodoamphetamine (n = 28). Voxel-based analyses were performed for ASL-MRI and SPECT using Mini-Mental State Examination (MMSE) scores as covariates. Differences in CBF between PLD1.5 and PLD2.5 were assessed using a paired t-test with SPM12. Results Significant positive correlations were observed between MMSE scores and CBF at PLD1.5 in the right posterior cingulate cortex (PCC), and both temporo-parietal association cortexes. At PLD2.5, significant positive correlations were determined for MMSE scores and CBF in the superior parietal lobule and the right temporo-parietal association cortex. SPECT showed significant positive correlations in the PCC and both temporo-parietal association cortexes (right-side dominant). PLD1.5 showed significantly higher CBF than PLD2.5 in the proximal areas of vascular territories of the anterior, middle, and posterior cerebral arteries. Conclusions Significant positive correlations in CBF, measured with both ASL-MRI and SPECT, with cognition were found in the PCC and temporo-parietal association cortexes. PLD1.5 and PLD2.5 showed similar correlations with cognition, although the CBF images had significant differences. |
| Databáze: | OpenAIRE |
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