Testing of drugs using human feto-maternal interface organ-on-chips provide insights into pharmacokinetics and efficacy

Autor:	Lauren S. Richardson, Ananth K. Kammala, Maged M. Costantine, Stephen J. Fortunato, Enkhtuya Radnaa, Sungjin Kim, Robert N. Taylor, Arum Han, Ramkumar Menon
Rok vydání:	2022
Předmět:	Pregnancy Tandem Mass Spectrometry Polyesters Biomedical Engineering Humans Cytokines Female Bioengineering General Chemistry Hydroxymethylglutaryl-CoA Reductase Inhibitors Biochemistry Chromatography Liquid
Zdroj:	Lab on a Chip. 22:4574-4592
ISSN:	1473-0189 1473-0197
DOI:	10.1039/d2lc00691j
Popis:	We developed multiple microfluidic organ-on-chip (OOC) devices that represent the structure, functions, and responses of the two feto-maternal interfaces (FMis) in humans (fetal membrane [FMi-OOC] and placenta [PLA-OOC]). Generated by BioRender.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e42dc61fd5a838721df0e8e72dcc2cc https://doi.org/10.1039/d2lc00691j Zobrazit plný text záznamu