The emerging role of WWP1 in cancer development and progression
Autor: | Xiaoli Hu, Zhiwei Wang, Renqian Feng, Zixia Lin, Gang Chen, Jiangtao Yu |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Cancer Research Immunology Review Article medicine.disease_cause 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine medicine Tumour-suppressor proteins RC254-282 biology QH573-671 business.industry Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Oncogenes Cell Biology medicine.disease Ubiquitin ligase Review article 030104 developmental biology Tumor progression 030220 oncology & carcinogenesis biology.protein Cancer research Cancer development business Carcinogenesis Cytology |
Zdroj: | Cell Death Discovery, Vol 7, Iss 1, Pp 1-8 (2021) Cell Death Discovery |
ISSN: | 2058-7716 |
Popis: | Emerging evidence demonstrates that WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) participates into carcinogenesis and tumor progression. In this review article, we will describe the association between dysregulated WWP1 expression and clinical features of cancer patients. Moreover, we summarize the both oncogenic and tumor suppressive functions of WWP1 in a variety of human cancers. Furthermore, we briefly describe the downstream substrates of WWP1 and its upstream factors to regulate the expression of WWP1. Notably, targeting WWP1 by its inhibitors or natural compounds is potentially useful for treating human malignancies. Finally, we provide the perspectives regarding WWP1 in cancer development and therapies. We hope this review can stimulate the research to improve our understanding of WWP1-mediated tumorigenesis and accelerate the discovery of novel therapeutic strategies via targeting WWP1 expression in cancers. |
Databáze: | OpenAIRE |
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