Maternal Serum Resistin Is Reduced in First Trimester Preeclampsia Pregnancies and Is a Marker of Clinical Severity

Autor:	Anting Liu Carlsen, Karen R. Wøjdemann, Line Rode, Paula L. Hedley, Jennifer M. Jørgensen, Ann Tabor, A. Gjerris, Sophie Placing, Michael Christiansen, Karin Sundberg, A. C. Shalmi
Rok vydání:	2015
Předmět:	Pregnancy medicine.medical_specialty business.industry Obstetrics Birth weight Obstetrics and Gynecology Gestational age medicine.disease Preeclampsia medicine.anatomical_structure Insulin resistance Placenta Internal Medicine medicine Resistin business Body mass index
Zdroj:	Hypertension in Pregnancy. 34:422-433
ISSN:	1525-6065 1064-1955
DOI:	10.3109/10641955.2014.913615
Popis:	Objective: To examine whether resistin levels in first trimester maternal serum are associated with insulin resistance or preeclampsia (PE). Methods: A case-control study of maternal serum resistin concentration conducted using 285 normal pregnancies and 123 PE pregnancies matched for gestational age, parity and maternal age. Samples were taken in gestational weeks 10+0–13+6. Results: There was a negative correlation between resistin and clinical severity of PE, but no correlation with IS, TNF-α, body mass index, birth weight and pregnancy length. Conclusions: Resistin is reduced in first trimester of PE pregnancies, particularly in severe PE. Inflammation and IS cannot explain this phenomenon.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e424854c1634a6be3e8bd9721f715d1 https://doi.org/10.3109/10641955.2014.913615 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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