A Scalable and Versatile Synthesis of Oxime-Based Hormone Dimers and Gels for Sustained Release
| Autor: | Zeyun Xiao, Luke A. Connal, Joe Collins, Daniel Klinger, Christopher W. Bennett |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_treatment
Molecular Conformation 02 engineering and technology 010402 general chemistry 01 natural sciences Biochemistry Steroid chemistry.chemical_compound Hydrolysis Oximes medicine chemistry.chemical_classification Organic Chemistry General Chemistry Polymer 021001 nanoscience & nanotechnology Oxime Controlled release Combinatorial chemistry Hormones 0104 chemical sciences Steroid hormone chemistry Click chemistry 0210 nano-technology Linker Dimerization Gels |
| Zdroj: | Chemistry, an Asian journal. 12(13) |
| ISSN: | 1861-471X |
| Popis: | Well-defined steroid hormone dimers and organogels were produced via a facile and scalable synthesis using oxime click chemistry. The versatile synthetic procedure extends to a wide range of hormones and linker groups exemplified here through the synthesis of cortisol- and progesterone-dimers linked via hydrophobic, hydrophilic or functional groups. This method was also extended to the synthesis of cortisone-based organogels. Owing to the dynamic nature of the oxime bond, the hormone-based materials are degradable via acidic hydrolysis and transoximination representing new materials for the controlled release of steroid hormones. |
| Databáze: | OpenAIRE |
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